loading...| Preferred Name |
granisetron hydrochloride |
|
| Synonyms |
GRAN |
|
| Definitions |
The hydrochloride salt of an indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1353" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1353" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042236 |
|
| altLabel |
GRAN |
|
| CAS Registry |
109889-09-0 |
|
| Component of | ||
| cui |
C0543476 C0061863 |
|
| Date last modified |
2017-06-19 |
|
| definition |
The hydrochloride salt of an indazole derivative with antiemetic properties. As a selective serotonin receptor antagonist, granisetron competitively blocks the action of serotonin at 5-hydroxytryptamine3 (5-HT3) receptors, resulting in the suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1353" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1353" NCI Thesaurus) |
|
| Legacy PDQ ID |
5485 |
|
| NCI ID |
C1353 |
|
| notation |
CDR0000042236 |
|
| NSC Code |
672814 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
granisetron hydrochloride |
|
| tui |
T109 T121 |