Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

imipenem

Synonyms

imipemide

Definitions

A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C570" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C570" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000042116

altLabel

imipemide

MK-0787

CAS Registry

74431-23-5

cui

C0020933

C0729073

definition

A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C570" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C570" NCI Thesaurus)

Legacy PDQ ID

5352

NCI ID

C570

notation

CDR0000042116

NSC Code

717864

ORIG STY

Drug/agent

prefLabel

imipenem

tui

T109

T195

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http://purl.bioontology.org/ontology/NDDF/002813 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002813 NDDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146319 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146319 NDFRT LOOM
http://stirdf.jst.go.jp/id/200907058218191280 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6568 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.124.300.500 RH-MESH LOOM
http://purl.bioontology.org/ontology/MSHFRE/D015378 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D015378 MSHFRE CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006281 NDFRT CUI
http://purl.obolibrary.org/obo/ARO_3000170 ARO LOOM
http://purl.obolibrary.org/obo/ARO_3000170 ARO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015378 RH-MESH LOOM
http://purl.bioontology.org/ontology/SCTSPA/424285002 SCTSPA CUI
http://purl.obolibrary.org/obo/CHEBI_471744 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_471744 NIFSTD LOOM
http://www.co-ode.org/ontologies/galen#Imipenem GALEN LOOM
http://purl.jp/bio/4/id/200906055426857435 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.124.300.500 RH-MESH LOOM
http://purl.obolibrary.org/obo/DRON_00017836 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00017836 DRON LOOM
http://purl.bioontology.org/ontology/SNMI/C-53750 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-53750 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-53750 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4017969 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017969 VANDF LOOM
http://purl.bioontology.org/ontology/SCTSPA/46558003 SCTSPA CUI
http://purl.bioontology.org/ontology/SNOMEDCT/424285002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/46558003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/46558003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D015378 MESH CUI
http://purl.bioontology.org/ontology/MESH/D015378 MESH CUI
http://purl.bioontology.org/ontology/MESH/D015378 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_5879 NIFSTD LOOM
http://purl.bioontology.org/ontology/RXNORM/5690 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/5690 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007072 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU007072 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C570 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C570 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020933 OCHV LOOM
http://purl.bioontology.org/ontology/LNC/LP15795-5 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP15795-5 LOINC LOOM