loading...| Preferred Name |
O6-benzylguanine |
|
| Synonyms |
BG |
|
| Definitions |
A guanine analogue with antineoplastic activity. O(6)-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1306" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1306" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042113 |
|
| altLabel |
BG 06-Benzyl Guanine O(6)-Benzylguanine O-6-Benzylguanine 06-Benzylguanine |
|
| CAS Registry |
19916-73-5 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000042114 http://purl.bioontology.org/ontology/PDQ/CDR0000037984 |
|
| cui |
C0083812 |
|
| Date last modified |
2006-09-07 |
|
| definition |
A guanine analogue with antineoplastic activity. O(6)-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1306" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1306" NCI Thesaurus) |
|
| IND Code |
45789 |
|
| Legacy PDQ ID |
5349 |
|
| NCI ID |
C1306 |
|
| notation |
CDR0000042113 |
|
| NSC Code |
637037 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
O6-benzylguanine |
|
| tui |
T114 T121 |