loading...| Preferred Name |
niacinamide |
|
| Synonyms |
Pellagra-Preventing Factor |
|
| Definitions |
The active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2327" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2327" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000042044 |
|
| altLabel |
Pellagra-Preventing Factor Nicotylamide Nicamid 3-Pyridinecarboxamide Nicotinic Acid Amide Nicosedine nicotinamide Nicotinamidum Vitamin PP |
|
| CAS Registry |
98-92-0 |
|
| Component of | ||
| cui |
C1518323 C1518322 C0028027 |
|
| Date last modified |
2006-08-31 |
|
| definition |
The active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C2327" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C2327" NCI Thesaurus) |
|
| Legacy PDQ ID |
5273 |
|
| LT |
TRD |
|
| NCI ID |
C2327 |
|
| notation |
CDR0000042044 |
|
| NSC Code |
27452 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
niacinamide |
|
| tui |
T109 T127 T121 |