Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

busulfan

Synonyms

1,4-bis(methanesulfonoxy)butane

Definitions

A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C321" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C321" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041947

altLabel

1,4-bis(methanesulfonoxy)butane

Misulban

WR-19508

Mylecytan

busulphan

glyzophrol

Myeleukon

Mitosan

Bussulfam

Mielucin

Busulfanum

BUS

Myleran

tetramethylene bis(methanesulfonate)

1,4-bitanediol dimethanesulfonate esters

Sulfabutin

1,4-butanediol dimethylsulfonate

BSF

GT-41

1,4-di(methylsulfonyloxy)butane

BU

methanesulfonic acid, tetramethylene ester

1,4-di(methanesulfonyloxy)butane

Busulfex

Misulfan

CB-2041

Myeloleukon

Myelosan

CAS Registry

55-98-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041142

http://purl.bioontology.org/ontology/PDQ/CDR0000269827

http://purl.bioontology.org/ontology/PDQ/CDR0000041577

http://purl.bioontology.org/ontology/PDQ/CDR0000041918

http://purl.bioontology.org/ontology/PDQ/CDR0000392734

http://purl.bioontology.org/ontology/PDQ/CDR0000040146

http://purl.bioontology.org/ontology/PDQ/CDR0000041525

http://purl.bioontology.org/ontology/PDQ/CDR0000285704

http://purl.bioontology.org/ontology/PDQ/CDR0000042248

http://purl.bioontology.org/ontology/PDQ/CDR0000041820

http://purl.bioontology.org/ontology/PDQ/CDR0000043100

http://purl.bioontology.org/ontology/PDQ/CDR0000042321

http://purl.bioontology.org/ontology/PDQ/CDR0000041150

http://purl.bioontology.org/ontology/PDQ/CDR0000041923

http://purl.bioontology.org/ontology/PDQ/CDR0000041921

http://purl.bioontology.org/ontology/PDQ/CDR0000043101

http://purl.bioontology.org/ontology/PDQ/CDR0000042634

http://purl.bioontology.org/ontology/PDQ/CDR0000043054

http://purl.bioontology.org/ontology/PDQ/CDR0000043056

http://purl.bioontology.org/ontology/PDQ/CDR0000041860

http://purl.bioontology.org/ontology/PDQ/CDR0000042956

http://purl.bioontology.org/ontology/PDQ/CDR0000043304

http://purl.bioontology.org/ontology/PDQ/CDR0000041824

http://purl.bioontology.org/ontology/PDQ/CDR0000042060

http://purl.bioontology.org/ontology/PDQ/CDR0000041697

http://purl.bioontology.org/ontology/PDQ/CDR0000038500

http://purl.bioontology.org/ontology/PDQ/CDR0000041922

http://purl.bioontology.org/ontology/PDQ/CDR0000041621

http://purl.bioontology.org/ontology/PDQ/CDR0000043728

http://purl.bioontology.org/ontology/PDQ/CDR0000041796

cui

C0728930

C0728928

C0939273

C0728926

C1511348

C0006463

C1522692

C1135149

C0728927

C1511349

C1522691

C0700015

C1522695

C0728924

Date last modified

2014-02-20

definition

A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C321" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C321" NCI Thesaurus)

Legacy PDQ ID

517

LT

TRD

NCI ID

C321

notation

CDR0000041947

NSC Code

750

ORIG STY

Drug/agent

prefLabel

busulfan

tui

T109

T131

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/RXNORM/284676 RXNORM CUI
http://purl.bioontology.org/ontology/MESH/D002066 MESH CUI
http://purl.bioontology.org/ontology/LNC/LP18783-8 LOINC CUI
http://purl.bioontology.org/ontology/MESH/D002066 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/203010 RXNORM CUI
http://purl.bioontology.org/ontology/MESH/D002066 MESH CUI
http://purl.bioontology.org/ontology/MESH/D002066 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147076 NDFRT CUI
http://purl.bioontology.org/ontology/CSP/2840-4511 CRISP CUI
http://purl.bioontology.org/ontology/NDDF/002638 NDDF CUI
http://purl.bioontology.org/ontology/SCTSPA/2571007 SCTSPA CUI
http://purl.bioontology.org/ontology/LNC/MTHU004760 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387138002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/LNC/LP416906-8 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007483 NDFRT CUI
http://purl.bioontology.org/ontology/MSHFRE/D002066 MSHFRE CUI
http://purl.bioontology.org/ontology/RXNORM/1828 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/387138002 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-78030 SNMI CUI
http://purl.bioontology.org/ontology/RCD/h11.. RCD CUI
http://purl.bioontology.org/ontology/VANDF/4018773 VANDF CUI
http://purl.bioontology.org/ontology/ATC/L01AB01 ATC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/2571007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D002066 MESH CUI
http://purl.bioontology.org/ontology/MESH/D002066 MESH CUI
http://purl.bioontology.org/ontology/RCD/x02kD RCD CUI
http://purl.bioontology.org/ontology/LNC/LP18783-8 LOINC LOOM
http://www.gamuts.net/entity#busulfan GAMUTS LOOM
http://purl.obolibrary.org/obo/MESH_D002066 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147076 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 VDOT LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 FB-CV LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_28901 PECO LOOM
http://purl.bioontology.org/ontology/CSP/2840-4511 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002066 RH-MESH LOOM
http://purl.jp/bio/4/id/200906012720303749 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/002638 NDDF LOOM
https://go.drugbank.com/drugs/DB01008 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004760 LOINC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015730 PMAPP-PMO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2245 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.455.125.125 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387138002 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP416906-8 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.326.146.100.050.500.100 RH-MESH LOOM
http://purl.obolibrary.org/obo/OMIT_0003415 OMIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C321 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/1828 RXNORM LOOM
http://purl.bioontology.org/ontology/SNMI/C-78030 SNMI LOOM
http://stirdf.jst.go.jp/id/200907009861821355 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4018773 VANDF LOOM
http://purl.bioontology.org/ontology/ATC/L01AB01 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0006463 OCHV LOOM
http://purl.obolibrary.org/obo/NCIT_C321 BERO LOOM
http://purl.bioontology.org/ontology/MESH/D002066 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.645.600.055.050.510.100 RH-MESH LOOM