loading...| Preferred Name |
fostriecin |
|
| Synonyms |
phosphotrienin |
|
| Definitions |
An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis in various malignant cell types. This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1372" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1372" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041703 |
|
| altLabel |
phosphotrienin FST 2H-pyran-2-one,5,6-dihydro-6-(3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11,-tridecatetraenyl)-,trans |
|
| CAS Registry |
87810-56-8 |
|
| cui |
C0118175 |
|
| definition |
An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis in various malignant cell types. This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1372" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1372" NCI Thesaurus) |
|
| IND Code |
39667 |
|
| Legacy PDQ ID |
4870 |
|
| NCI ID |
C1372 |
|
| notation |
CDR0000041703 |
|
| NSC Code |
339638 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
fostriecin |
|
| tui |
T109 T121 |