Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

temozolomide

Synonyms

Temomedac

Definitions

A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1244" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1244" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041671

altLabel

Temomedac

SCH 52365

TMZ

imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-

8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one

3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide

M and B 39831

CCRG-81045

Temodar

Temodal

M & B 39831

RP-46161

Temcad

CAS Registry

85622-93-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000361541

http://purl.bioontology.org/ontology/PDQ/CDR0000257909

http://purl.bioontology.org/ontology/PDQ/CDR0000433523

http://purl.bioontology.org/ontology/PDQ/CDR0000355821

http://purl.bioontology.org/ontology/PDQ/CDR0000038026

http://purl.bioontology.org/ontology/PDQ/CDR0000038450

http://purl.bioontology.org/ontology/PDQ/CDR0000442408

http://purl.bioontology.org/ontology/PDQ/CDR0000372896

http://purl.bioontology.org/ontology/PDQ/CDR0000405999

http://purl.bioontology.org/ontology/PDQ/CDR0000429561

http://purl.bioontology.org/ontology/PDQ/CDR0000301904

http://purl.bioontology.org/ontology/PDQ/CDR0000405845

http://purl.bioontology.org/ontology/PDQ/CDR0000433522

http://purl.bioontology.org/ontology/PDQ/CDR0000257908

http://purl.bioontology.org/ontology/PDQ/CDR0000038068

http://purl.bioontology.org/ontology/PDQ/CDR0000038606

http://purl.bioontology.org/ontology/PDQ/CDR0000257906

http://purl.bioontology.org/ontology/PDQ/CDR0000038502

http://purl.bioontology.org/ontology/PDQ/CDR0000433525

http://purl.bioontology.org/ontology/PDQ/CDR0000037984

http://purl.bioontology.org/ontology/PDQ/CDR0000043450

http://purl.bioontology.org/ontology/PDQ/CDR0000375023

http://purl.bioontology.org/ontology/PDQ/CDR0000371721

http://purl.bioontology.org/ontology/PDQ/CDR0000038492

http://purl.bioontology.org/ontology/PDQ/CDR0000038000

http://purl.bioontology.org/ontology/PDQ/CDR0000445605

http://purl.bioontology.org/ontology/PDQ/CDR0000042228

http://purl.bioontology.org/ontology/PDQ/CDR0000433524

http://purl.bioontology.org/ontology/PDQ/CDR0000352306

http://purl.bioontology.org/ontology/PDQ/CDR0000038464

http://purl.bioontology.org/ontology/PDQ/CDR0000037975

http://purl.bioontology.org/ontology/PDQ/CDR0000405846

http://purl.bioontology.org/ontology/PDQ/CDR0000043341

http://purl.bioontology.org/ontology/PDQ/CDR0000340966

http://purl.bioontology.org/ontology/PDQ/CDR0000037788

cui

C1524087

C0876179

C0108742

C4082706

C0701506

C0076080

C4287817

C4087085

C0126551

Date last modified

2016-02-22

definition

A triazene analog of dacarbazine with antineoplastic activity. As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of DNA replication. Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1244" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1244" NCI Thesaurus)

IND Code

42084

Legacy PDQ ID

4834

LT

TRD

NCI ID

C1244

notation

CDR0000041671

NSC Code

362856

ORIG STY

Drug/agent

prefLabel

temozolomide

tui

T109

T121

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http://purl.bioontology.org/ontology/UATC/L01AX03 ATC CUI
http://purl.bioontology.org/ontology/UATC/L01AX03 ATC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14908 OCHV LOOM
http://purl.bioontology.org/ontology/MSHFRE/D000077204 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077204 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D000077204 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D000077204 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077204 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077204 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077204 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077204 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077204 MESH LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1244 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1244 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/261663 RXNORM CUI
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_72564 CHEBI LOOM
http://purl.bioontology.org/ontology/NDDF/007794 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/007794 NDDF LOOM
http://purl.jp/bio/4/id/200906010256487782 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148622 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148622 NDFRT LOOM
http://purl.obolibrary.org/obo/DRON_00017608 DRON LOOM
http://purl.obolibrary.org/obo/DRON_00017608 DRON LOOM
http://purl.bioontology.org/ontology/SCTSPA/387009002 SCTSPA CUI
http://www.ifomis.org/acgt/1.0#Temozolomide ACGT-MO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387009002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387009002 SNOMEDCT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0076080 OCHV LOOM
http://purl.bioontology.org/ontology/CSP/4008-0098 CRISP CUI
http://purl.bioontology.org/ontology/CSP/4008-0098 CRISP CUI
http://purl.bioontology.org/ontology/CSP/4008-0098 CRISP LOOM
http://purl.bioontology.org/ontology/RXNORM/37776 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/37776 RXNORM LOOM
http://www.co-ode.org/ontologies/galen#Temozolomide GALEN LOOM
http://stirdf.jst.go.jp/id/200907074216809916 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/116099008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006455 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/116099008 SCTSPA CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C047246 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4021173 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4021173 VANDF LOOM