loading...| Preferred Name |
lovastatin |
|
| Synonyms |
Monacolin K |
|
| Definitions |
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C620" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C620" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041658 |
|
| altLabel |
Monacolin K Mevacor Mevinolin (2S)-2-methylbutanoic acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester Lovastatin Sodium |
|
| CAS Registry |
75330-75-5 |
|
| cui |
C1708744 C0024027 C0728780 |
|
| definition |
A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering and potential antineoplastic activities. Lovastatin is hydrolyzed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in cholesterol biosynthesis. In addition, this agent may induce tumor cell apoptosis and inhibit tumor cell invasiveness, possibly by inhibiting protein farnesylation and protein geranylgeranylation, and may arrest cells in the G1 phase of the cell cycle. The latter effect sensitizes tumor cells to the cytotoxic effects of ionizing radiation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C620" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C620" NCI Thesaurus) |
|
| IND Code |
46181 |
|
| Legacy PDQ ID |
2008-02-21 |
|
| LT |
TRD |
|
| NCI ID |
C620 |
|
| notation |
CDR0000041658 |
|
| NSC Code |
633781 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
lovastatin |
|
| tui |
T109 T121 |