Physician Data Query

Last uploaded: April 29, 2019
Preferred Name

docetaxel

Synonyms

TXT

Definitions

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41657&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41657&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1526" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041657

altLabel

TXT

RP 56976

[2aR-[2a Alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester

Taxotere

RP56976

N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol

CAS Registry

114977-28-5

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000038667

http://purl.bioontology.org/ontology/PDQ/CDR0000038486

http://purl.bioontology.org/ontology/PDQ/CDR0000037859

http://purl.bioontology.org/ontology/PDQ/CDR0000043257

http://purl.bioontology.org/ontology/PDQ/CDR0000042701

http://purl.bioontology.org/ontology/PDQ/CDR0000037876

http://purl.bioontology.org/ontology/PDQ/CDR0000038122

http://purl.bioontology.org/ontology/PDQ/CDR0000437254

http://purl.bioontology.org/ontology/PDQ/CDR0000043014

http://purl.bioontology.org/ontology/PDQ/CDR0000042539

http://purl.bioontology.org/ontology/PDQ/CDR0000042336

http://purl.bioontology.org/ontology/PDQ/CDR0000377521

http://purl.bioontology.org/ontology/PDQ/CDR0000334947

http://purl.bioontology.org/ontology/PDQ/CDR0000043150

http://purl.bioontology.org/ontology/PDQ/CDR0000042221

http://purl.bioontology.org/ontology/PDQ/CDR0000378336

http://purl.bioontology.org/ontology/PDQ/CDR0000042530

http://purl.bioontology.org/ontology/PDQ/CDR0000038480

http://purl.bioontology.org/ontology/PDQ/CDR0000038684

http://purl.bioontology.org/ontology/PDQ/CDR0000038365

http://purl.bioontology.org/ontology/PDQ/CDR0000256467

http://purl.bioontology.org/ontology/PDQ/CDR0000358333

http://purl.bioontology.org/ontology/PDQ/CDR0000288842

http://purl.bioontology.org/ontology/PDQ/CDR0000420970

http://purl.bioontology.org/ontology/PDQ/CDR0000037836

http://purl.bioontology.org/ontology/PDQ/CDR0000405881

http://purl.bioontology.org/ontology/PDQ/CDR0000043383

http://purl.bioontology.org/ontology/PDQ/CDR0000038527

http://purl.bioontology.org/ontology/PDQ/CDR0000038449

http://purl.bioontology.org/ontology/PDQ/CDR0000445459

http://purl.bioontology.org/ontology/PDQ/CDR0000410774

http://purl.bioontology.org/ontology/PDQ/CDR0000043499

http://purl.bioontology.org/ontology/PDQ/CDR0000038493

http://purl.bioontology.org/ontology/PDQ/CDR0000372907

http://purl.bioontology.org/ontology/PDQ/CDR0000322262

http://purl.bioontology.org/ontology/PDQ/CDR0000256414

http://purl.bioontology.org/ontology/PDQ/CDR0000357873

http://purl.bioontology.org/ontology/PDQ/CDR0000043486

http://purl.bioontology.org/ontology/PDQ/CDR0000443025

http://purl.bioontology.org/ontology/PDQ/CDR0000355803

http://purl.bioontology.org/ontology/PDQ/CDR0000306450

http://purl.bioontology.org/ontology/PDQ/CDR0000038668

http://purl.bioontology.org/ontology/PDQ/CDR0000038270

http://purl.bioontology.org/ontology/PDQ/CDR0000358058

http://purl.bioontology.org/ontology/PDQ/CDR0000358199

http://purl.bioontology.org/ontology/PDQ/CDR0000372886

http://purl.bioontology.org/ontology/PDQ/CDR0000042335

http://purl.bioontology.org/ontology/PDQ/CDR0000361542

http://purl.bioontology.org/ontology/PDQ/CDR0000437138

http://purl.bioontology.org/ontology/PDQ/CDR0000038364

http://purl.bioontology.org/ontology/PDQ/CDR0000043335

http://purl.bioontology.org/ontology/PDQ/CDR0000393518

http://purl.bioontology.org/ontology/PDQ/CDR0000357522

http://purl.bioontology.org/ontology/PDQ/CDR0000380852

http://purl.bioontology.org/ontology/PDQ/CDR0000386169

http://purl.bioontology.org/ontology/PDQ/CDR0000423473

http://purl.bioontology.org/ontology/PDQ/CDR0000037931

http://purl.bioontology.org/ontology/PDQ/CDR0000388010

http://purl.bioontology.org/ontology/PDQ/CDR0000258338

http://purl.bioontology.org/ontology/PDQ/CDR0000269167

http://purl.bioontology.org/ontology/PDQ/CDR0000043382

http://purl.bioontology.org/ontology/PDQ/CDR0000038302

http://purl.bioontology.org/ontology/PDQ/CDR0000038267

http://purl.bioontology.org/ontology/PDQ/CDR0000334874

http://purl.bioontology.org/ontology/PDQ/CDR0000038695

http://purl.bioontology.org/ontology/PDQ/CDR0000353339

http://purl.bioontology.org/ontology/PDQ/CDR0000368788

http://purl.bioontology.org/ontology/PDQ/CDR0000358327

http://purl.bioontology.org/ontology/PDQ/CDR0000038075

http://purl.bioontology.org/ontology/PDQ/CDR0000430107

http://purl.bioontology.org/ontology/PDQ/CDR0000330214

http://purl.bioontology.org/ontology/PDQ/CDR0000352178

http://purl.bioontology.org/ontology/PDQ/CDR0000043229

http://purl.bioontology.org/ontology/PDQ/CDR0000043108

http://purl.bioontology.org/ontology/PDQ/CDR0000374992

http://purl.bioontology.org/ontology/PDQ/CDR0000037838

http://purl.bioontology.org/ontology/PDQ/CDR0000037868

http://purl.bioontology.org/ontology/PDQ/CDR0000352150

http://purl.bioontology.org/ontology/PDQ/CDR0000445418

http://purl.bioontology.org/ontology/PDQ/CDR0000042962

http://purl.bioontology.org/ontology/PDQ/CDR0000352014

http://purl.bioontology.org/ontology/PDQ/CDR0000442106

http://purl.bioontology.org/ontology/PDQ/CDR0000042813

http://purl.bioontology.org/ontology/PDQ/CDR0000299071

http://purl.bioontology.org/ontology/PDQ/CDR0000042151

http://purl.bioontology.org/ontology/PDQ/CDR0000368454

http://purl.bioontology.org/ontology/PDQ/CDR0000038346

http://purl.bioontology.org/ontology/PDQ/CDR0000038303

http://purl.bioontology.org/ontology/PDQ/CDR0000043347

http://purl.bioontology.org/ontology/PDQ/CDR0000420843

http://purl.bioontology.org/ontology/PDQ/CDR0000269485

http://purl.bioontology.org/ontology/PDQ/CDR0000037906

http://purl.bioontology.org/ontology/PDQ/CDR0000043062

http://purl.bioontology.org/ontology/PDQ/CDR0000257389

http://purl.bioontology.org/ontology/PDQ/CDR0000355818

http://purl.bioontology.org/ontology/PDQ/CDR0000373961

http://purl.bioontology.org/ontology/PDQ/CDR0000315653

http://purl.bioontology.org/ontology/PDQ/CDR0000357941

http://purl.bioontology.org/ontology/PDQ/CDR0000043643

http://purl.bioontology.org/ontology/PDQ/CDR0000322130

http://purl.bioontology.org/ontology/PDQ/CDR0000257137

http://purl.bioontology.org/ontology/PDQ/CDR0000389265

http://purl.bioontology.org/ontology/PDQ/CDR0000415310

http://purl.bioontology.org/ontology/PDQ/CDR0000391173

http://purl.bioontology.org/ontology/PDQ/CDR0000042531

http://purl.bioontology.org/ontology/PDQ/CDR0000042633

http://purl.bioontology.org/ontology/PDQ/CDR0000339958

http://purl.bioontology.org/ontology/PDQ/CDR0000343780

http://purl.bioontology.org/ontology/PDQ/CDR0000422409

http://purl.bioontology.org/ontology/PDQ/CDR0000038366

http://purl.bioontology.org/ontology/PDQ/CDR0000357560

http://purl.bioontology.org/ontology/PDQ/CDR0000037969

http://purl.bioontology.org/ontology/PDQ/CDR0000038710

http://purl.bioontology.org/ontology/PDQ/CDR0000038699

http://purl.bioontology.org/ontology/PDQ/CDR0000043593

http://purl.bioontology.org/ontology/PDQ/CDR0000038209

http://purl.bioontology.org/ontology/PDQ/CDR0000352013

http://purl.bioontology.org/ontology/PDQ/CDR0000271334

http://purl.bioontology.org/ontology/PDQ/CDR0000409702

http://purl.bioontology.org/ontology/PDQ/CDR0000038545

cui

C0699967

C0771375

C0733872

C0246415

Date last modified

2006-08-01

definition

A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata. Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41657&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41657&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1526" NCI Thesaurus)

IND Code

40466

Legacy PDQ ID

4819

LT

TRD

NCI ID

C1526

notation

CDR0000041657

NSC Code

628503

ORIG STY

Drug/agent

prefLabel

docetaxel

tui

T109

T121

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http://purl.bioontology.org/ontology/CSP/0093-3150 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0093-3150 CRISP CUI
http://purl.bioontology.org/ontology/RCD/x03cn RCD CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C067311 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4020968 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4020968 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/72962 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/72962 RXNORM LOOM
http://purl.bioontology.org/ontology/RXNORM/202982 RXNORM CUI
http://www.semanticweb.org/ontologies/2018/1/ProstateCancer.owl#Docetaxel PCAO LOOM
http://purl.bioontology.org/ontology/MESH/D000077143 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077143 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077143 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077143 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077143 MESH LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148441 ODAE LOOM
http://www.co-ode.org/ontologies/galen#Docetaxel GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000005739 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386918005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386918005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/h5E.. RCD CUI
http://purl.bioontology.org/ontology/RCD/h5E.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148441 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148441 NDFRT LOOM
http://www.ifomis.org/acgt/1.0#Docetaxel ACGT-MO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108806006 SNOMEDCT CUI
http://d-nb.info/gnd/4501869-8 FAST-TOPICAL LOOM
http://www.drugbank.ca/drugs/DB01248 FTC LOOM
http://purl.jp/bio/4/id/200906091109109292 IOBC LOOM
http://purl.jp/bio/4/id/200906091109109292 IOBC LOOM
http://purl.jp/bio/4/id/200906091109109292 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/L01CD02 ATC CUI
http://purl.bioontology.org/ontology/UATC/L01CD02 ATC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 ROO LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1526 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/1299922 RXNORM CUI
http://stirdf.jst.go.jp/id/200907094393798330 IOBC LOOM
http://stirdf.jst.go.jp/id/200907094393798330 IOBC LOOM
http://stirdf.jst.go.jp/id/200907094393798330 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/005187 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/005187 NDDF LOOM
http://purl.bioontology.org/ontology/NDDF/005188 NDDF CUI