Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

sulindac

Synonyms

Clisundac

Definitions

A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41538&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41538&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C850" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041538

altLabel

Clisundac

Sulreuma

Sulinol

Reumofil

cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid

MK-231

Sulindac Sulfoxide

Reumyl

Aflodac

Arthrocine

Artribid

Imbaral

SULIN

Clinoril

Algocetil

(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid

Sudac

Apo-Sulin

Novo-Sundac

Citireuma

CAS Registry

38194-50-2

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000038667

http://purl.bioontology.org/ontology/PDQ/CDR0000037982

http://purl.bioontology.org/ontology/PDQ/CDR0000327787

http://purl.bioontology.org/ontology/PDQ/CDR0000038251

cui

C4082796

C1515047

C1515038

C0733670

C1515050

C1515046

C1515039

C1515042

C1515049

C0591267

C1515044

C1515043

C0038792

C1515040

C1515045

C1515041

C1515048

Date last modified

2006-05-22

definition

A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41538&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41538&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C850" NCI Thesaurus)

LT

TRD

NCI ID

C850

notation

CDR0000041538

ORIG STY

Drug/agent

prefLabel

sulindac

tui

T109

T121

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