loading...| Preferred Name |
sulindac |
|
| Synonyms |
Apo-Sulin |
|
| Definitions |
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C850" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C850" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041538 |
|
| altLabel |
Apo-Sulin Sulindac Sulfoxide (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid Aflodac Algocetil Reumofil Citireuma Sulreuma Novo-Sundac Arthrocine Sudac Imbaral Clinoril Sulinol Reumyl cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid MK-231 Artribid Clisundac SULIN |
|
| CAS Registry |
38194-50-2 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038251 http://purl.bioontology.org/ontology/PDQ/CDR0000038667 |
|
| cui |
C0733670 C1515039 C1515044 C1515048 C1515042 C1515043 C1515045 C1515049 C1515047 C1515041 C0038792 C0591267 C1515038 C1515050 C4082796 C1515046 C1515040 |
|
| Date last modified |
2006-05-22 |
|
| definition |
A sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C850" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C850" NCI Thesaurus) |
|
| LT |
TRD |
|
| NCI ID |
C850 |
|
| notation |
CDR0000041538 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
sulindac |
|
| tui |
T109 T121 |