Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

pentoxifylline

Synonyms

PTX

Definitions

A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41432&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41432&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C733" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041432

altLabel

PTX

Trental

Pentoxyphylline

3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione

oxpentifylline

CAS Registry

6493-05-6

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041904

http://purl.bioontology.org/ontology/PDQ/CDR0000041506

http://purl.bioontology.org/ontology/PDQ/CDR0000041921

http://purl.bioontology.org/ontology/PDQ/CDR0000038372

http://purl.bioontology.org/ontology/PDQ/CDR0000042054

http://purl.bioontology.org/ontology/PDQ/CDR0000042811

http://purl.bioontology.org/ontology/PDQ/CDR0000041923

http://purl.bioontology.org/ontology/PDQ/CDR0000041436

http://purl.bioontology.org/ontology/PDQ/CDR0000041870

http://purl.bioontology.org/ontology/PDQ/CDR0000042206

http://purl.bioontology.org/ontology/PDQ/CDR0000042812

http://purl.bioontology.org/ontology/PDQ/CDR0000043082

cui

C0030899

C0699487

definition

A methylxanthine derivative with hemorrheologic and immunomodulating properties. Pentoxifylline inhibits phosphodiesterase, resulting in increased levels of cyclic adenosine monophosphate (cAMP) in erythrocytes, endothelium, and the surrounding tissues. This leads to vasodilation, improves erythrocyte flexibility, and enhances blood flow. In addition, the increased level of cAMP in platelets inhibits platelet aggregation, which may contribute to a reduction in blood viscosity. This agent also inhibits production of tumor necrosis factor-alpha and interferon-gamma, while it induces Th2-like (T-helper 2) cytokine production, thereby inhibiting Th1-mediated (T-helper 1) inflammatory and autoimmune responses. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41432&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41432&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C733" NCI Thesaurus)

Legacy PDQ ID

4502

LT

TRD

NCI ID

C733

notation

CDR0000041432

NSC Code

637086

ORIG STY

Drug/agent

prefLabel

pentoxifylline

tui

T109

T121

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http://purl.jp/bio/4/id/200906055042872488 IOBC LOOM
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http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
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http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_7986 CHEBI LOOM
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http://stirdf.jst.go.jp/id/200907035146649783 IOBC LOOM
http://stirdf.jst.go.jp/id/200907035146649783 IOBC LOOM
http://stirdf.jst.go.jp/id/200907035146649783 IOBC LOOM
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http://purl.bioontology.org/ontology/UATC/C04AD03 ATC LOOM
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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733 NCIT LOOM
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http://www.drugbank.ca/drugs/DB00806 FTC LOOM
http://data.bnf.fr/ark:/12148/cb121985521 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002178 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387522004 SNOMEDCT CUI
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