loading...| Preferred Name |
bicalutamide |
|
| Synonyms |
ICI 176334 |
|
| Definitions |
A synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1599" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1599" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041298 |
|
| altLabel |
ICI 176334 N-[4-cyano-3-(trifluoromethyl)phenyl]3-3[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide Casodex ICI 176,334 Cosudex CDX 4'-cyano-alpha,alpha,alpha-trifuloro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide 4-cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline ICI-176334 (+/-)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide |
|
| CAS Registry |
90357-06-5 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000363904 http://purl.bioontology.org/ontology/PDQ/CDR0000357941 http://purl.bioontology.org/ontology/PDQ/CDR0000285615 http://purl.bioontology.org/ontology/PDQ/CDR0000357873 http://purl.bioontology.org/ontology/PDQ/CDR0000042914 http://purl.bioontology.org/ontology/PDQ/CDR0000410696 http://purl.bioontology.org/ontology/PDQ/CDR0000428223 http://purl.bioontology.org/ontology/PDQ/CDR0000041769 http://purl.bioontology.org/ontology/PDQ/CDR0000041770 http://purl.bioontology.org/ontology/PDQ/CDR0000038562 http://purl.bioontology.org/ontology/PDQ/CDR0000354489 http://purl.bioontology.org/ontology/PDQ/CDR0000043652 |
|
| cui |
C0591237 C0740019 C0285590 |
|
| Date last modified |
2016-04-22 |
|
| definition |
A synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1599" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1599" NCI Thesaurus) |
|
| Legacy PDQ ID |
4371 |
|
| LT |
TRD |
|
| NCI ID |
C1599 |
|
| notation |
CDR0000041298 |
|
| NSC Code |
950118 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
bicalutamide |
|
| tui |
T109 T121 |