Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

quinine

Synonyms

QUIN

Definitions

A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C794" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C794" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041253

altLabel

QUIN

CAS Registry

130-95-0

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041807

http://purl.bioontology.org/ontology/PDQ/CDR0000041447

http://purl.bioontology.org/ontology/PDQ/CDR0000041262

http://purl.bioontology.org/ontology/PDQ/CDR0000041475

http://purl.bioontology.org/ontology/PDQ/CDR0000041846

cui

C0034417

definition

A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C794" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C794" NCI Thesaurus)

Legacy PDQ ID

4326

NCI ID

C794

notation

CDR0000041253

NSC Code

192949

ORIG STY

Drug/agent

prefLabel

quinine

tui

T109

T121

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http://purl.bioontology.org/ontology/VANDF/4019926 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4019926 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148011 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000148011 NDFRT LOOM
http://purl.bioontology.org/ontology/CPT/84228 CPT LOOM
http://purl.bioontology.org/ontology/NDDF/002934 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002934 NDDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.810.762 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D011803 MESH CUI
http://purl.bioontology.org/ontology/MESH/D011803 MESH LOOM
http://purl.jp/bio/4/id/200906007668213171 IOBC LOOM
http://id.loc.gov/authorities/subjects/sh85109880 FAST-TOPICAL LOOM
http://www.drugbank.ca/drugs/DB00468 FTC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.605.687.762 RH-MESH LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Quinine APAONTO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU007609 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU007609 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/2532-8110 CRISP CUI
http://purl.bioontology.org/ontology/CSP/2532-8110 CRISP LOOM
http://stirdf.jst.go.jp/id/200907026656606974 IOBC LOOM
http://purl.bioontology.org/ontology/RXNORM/9071 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/9071 RXNORM LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/47065008 SNOMEDCT CUI
http://purl.obolibrary.org/obo/CHEBI_15854 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 HINO LOOM
http://purl.obolibrary.org/obo/CHEBI_15854 NIFSTD LOOM
http://www.co-ode.org/ontologies/galen#Quinine GALEN LOOM
http://purl.obolibrary.org/obo/IDOMAL_0000233 IDOMAL LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011803 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.132.206.719 RH-MESH LOOM
http://purl.bioontology.org/ontology/SCTSPA/373497008 SCTSPA CUI
http://data.bnf.fr/ark:/12148/cb11940835j FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SCTSPA/47065008 SCTSPA CUI
http://sbmi.uth.tmc.edu/ontology/ochv#10497 OCHV LOOM
http://purl.bioontology.org/ontology/MSHFRE/D011803 MSHFRE CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373497008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373497008 SNOMEDCT LOOM
http://localhost/plosthes.2017-1#847 PLOSTHES LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006109 FASTO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006109 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006109 DMTO LOOM
http://purl.bioontology.org/ontology/RCD/ej7.. RCD CUI
http://purl.bioontology.org/ontology/RCD/ej7.. RCD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0034417 OCHV LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006111 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0006111 DMTO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000006907 NDFRT CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C794 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C794 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C794 NCIT LOOM
http://purl.bioontology.org/ontology/LNC/LP16273-2 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP16273-2 LOINC LOOM
http://purl.bioontology.org/ontology/SNMI/C-56550 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-56550 SNMI LOOM
http://purl.bioontology.org/ontology/UATC/P01BC01 ATC CUI
http://purl.bioontology.org/ontology/UATC/P01BC01 ATC LOOM