loading...| Preferred Name |
ethacrynic acid |
|
| Synonyms |
Edecrin |
|
| Definitions |
An aryloxy-acetic acid derivative belonging to the class of loop diuretics. Ethacrynic acid interferes with the chloride binding site of the Na+, K+, Cl- cotransporter system in the thick ascending loop of Henle, thereby inhibiting the reabsorption of sodium, potassium, and chloride ions. This leads to an increase in the excretion of sodium, potassium, chloride, calcium, and water. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C485" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C485" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000041163 |
|
| altLabel |
Edecrin EA [2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic Acid |
|
| CAS Registry |
58-54-8 |
|
| Component of | ||
| cui |
C0014963 C0591434 |
|
| Date last modified |
2008-10-14 |
|
| definition |
An aryloxy-acetic acid derivative belonging to the class of loop diuretics. Ethacrynic acid interferes with the chloride binding site of the Na+, K+, Cl- cotransporter system in the thick ascending loop of Henle, thereby inhibiting the reabsorption of sodium, potassium, and chloride ions. This leads to an increase in the excretion of sodium, potassium, chloride, calcium, and water. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C485" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C485" NCI Thesaurus) |
|
| Legacy PDQ ID |
4236 |
|
| LT |
TRD |
|
| NCI ID |
C485 |
|
| notation |
CDR0000041163 |
|
| NSC Code |
85791 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ethacrynic acid |
|
| tui |
T109 T121 |