Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

asparaginase

Synonyms

Elspar

Definitions

An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C286" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C286" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000041146

altLabel

Elspar

Re-82-TAD-15

L-asparagine amidohydrolase

Lcf-ASP

Kidrolase

ASP-1

Laspar

Leunase

Leucogen

MK-965

asparaginase II

L-asparaginase

Spectrila

L-ASP

L-Asnase

Colaspase

Paronal

CAS Registry

9015-68-3

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000040601

http://purl.bioontology.org/ontology/PDQ/CDR0000041034

http://purl.bioontology.org/ontology/PDQ/CDR0000039325

http://purl.bioontology.org/ontology/PDQ/CDR0000041784

http://purl.bioontology.org/ontology/PDQ/CDR0000039042

http://purl.bioontology.org/ontology/PDQ/CDR0000039186

http://purl.bioontology.org/ontology/PDQ/CDR0000038858

http://purl.bioontology.org/ontology/PDQ/CDR0000038701

http://purl.bioontology.org/ontology/PDQ/CDR0000041031

http://purl.bioontology.org/ontology/PDQ/CDR0000039631

http://purl.bioontology.org/ontology/PDQ/CDR0000041350

http://purl.bioontology.org/ontology/PDQ/CDR0000040906

http://purl.bioontology.org/ontology/PDQ/CDR0000037927

http://purl.bioontology.org/ontology/PDQ/CDR0000038700

http://purl.bioontology.org/ontology/PDQ/CDR0000041032

http://purl.bioontology.org/ontology/PDQ/CDR0000043306

http://purl.bioontology.org/ontology/PDQ/CDR0000041875

http://purl.bioontology.org/ontology/PDQ/CDR0000041500

http://purl.bioontology.org/ontology/PDQ/CDR0000038875

http://purl.bioontology.org/ontology/PDQ/CDR0000038398

http://purl.bioontology.org/ontology/PDQ/CDR0000039772

http://purl.bioontology.org/ontology/PDQ/CDR0000041501

http://purl.bioontology.org/ontology/PDQ/CDR0000040572

http://purl.bioontology.org/ontology/PDQ/CDR0000041637

http://purl.bioontology.org/ontology/PDQ/CDR0000043395

http://purl.bioontology.org/ontology/PDQ/CDR0000043397

http://purl.bioontology.org/ontology/PDQ/CDR0000040161

http://purl.bioontology.org/ontology/PDQ/CDR0000043398

http://purl.bioontology.org/ontology/PDQ/CDR0000038879

http://purl.bioontology.org/ontology/PDQ/CDR0000042416

http://purl.bioontology.org/ontology/PDQ/CDR0000041111

http://purl.bioontology.org/ontology/PDQ/CDR0000038877

http://purl.bioontology.org/ontology/PDQ/CDR0000043402

http://purl.bioontology.org/ontology/PDQ/CDR0000041594

http://purl.bioontology.org/ontology/PDQ/CDR0000043680

http://purl.bioontology.org/ontology/PDQ/CDR0000039040

http://purl.bioontology.org/ontology/PDQ/CDR0000043135

http://purl.bioontology.org/ontology/PDQ/CDR0000041040

http://purl.bioontology.org/ontology/PDQ/CDR0000041673

http://purl.bioontology.org/ontology/PDQ/CDR0000040892

http://purl.bioontology.org/ontology/PDQ/CDR0000041312

http://purl.bioontology.org/ontology/PDQ/CDR0000039044

http://purl.bioontology.org/ontology/PDQ/CDR0000043401

http://purl.bioontology.org/ontology/PDQ/CDR0000043394

http://purl.bioontology.org/ontology/PDQ/CDR0000043295

http://purl.bioontology.org/ontology/PDQ/CDR0000040891

http://purl.bioontology.org/ontology/PDQ/CDR0000040907

http://purl.bioontology.org/ontology/PDQ/CDR0000038733

http://purl.bioontology.org/ontology/PDQ/CDR0000043357

http://purl.bioontology.org/ontology/PDQ/CDR0000043294

http://purl.bioontology.org/ontology/PDQ/CDR0000039039

http://purl.bioontology.org/ontology/PDQ/CDR0000041733

http://purl.bioontology.org/ontology/PDQ/CDR0000039629

http://purl.bioontology.org/ontology/PDQ/CDR0000038308

http://purl.bioontology.org/ontology/PDQ/CDR0000041493

http://purl.bioontology.org/ontology/PDQ/CDR0000038731

http://purl.bioontology.org/ontology/PDQ/CDR0000041782

http://purl.bioontology.org/ontology/PDQ/CDR0000042362

http://purl.bioontology.org/ontology/PDQ/CDR0000041832

http://purl.bioontology.org/ontology/PDQ/CDR0000042394

http://purl.bioontology.org/ontology/PDQ/CDR0000039524

http://purl.bioontology.org/ontology/PDQ/CDR0000041311

http://purl.bioontology.org/ontology/PDQ/CDR0000042396

http://purl.bioontology.org/ontology/PDQ/CDR0000041783

http://purl.bioontology.org/ontology/PDQ/CDR0000038287

http://purl.bioontology.org/ontology/PDQ/CDR0000039334

http://purl.bioontology.org/ontology/PDQ/CDR0000038291

http://purl.bioontology.org/ontology/PDQ/CDR0000043305

http://purl.bioontology.org/ontology/PDQ/CDR0000039624

http://purl.bioontology.org/ontology/PDQ/CDR0000039565

http://purl.bioontology.org/ontology/PDQ/CDR0000043405

http://purl.bioontology.org/ontology/PDQ/CDR0000037785

http://purl.bioontology.org/ontology/PDQ/CDR0000043403

http://purl.bioontology.org/ontology/PDQ/CDR0000041735

http://purl.bioontology.org/ontology/PDQ/CDR0000039634

http://purl.bioontology.org/ontology/PDQ/CDR0000041490

http://purl.bioontology.org/ontology/PDQ/CDR0000042427

http://purl.bioontology.org/ontology/PDQ/CDR0000038523

http://purl.bioontology.org/ontology/PDQ/CDR0000038307

http://purl.bioontology.org/ontology/PDQ/CDR0000043298

http://purl.bioontology.org/ontology/PDQ/CDR0000037925

http://purl.bioontology.org/ontology/PDQ/CDR0000043396

http://purl.bioontology.org/ontology/PDQ/CDR0000038577

http://purl.bioontology.org/ontology/PDQ/CDR0000038887

http://purl.bioontology.org/ontology/PDQ/CDR0000041033

http://purl.bioontology.org/ontology/PDQ/CDR0000042409

http://purl.bioontology.org/ontology/PDQ/CDR0000040819

http://purl.bioontology.org/ontology/PDQ/CDR0000043404

http://purl.bioontology.org/ontology/PDQ/CDR0000043400

http://purl.bioontology.org/ontology/PDQ/CDR0000041732

http://purl.bioontology.org/ontology/PDQ/CDR0000042412

http://purl.bioontology.org/ontology/PDQ/CDR0000039521

http://purl.bioontology.org/ontology/PDQ/CDR0000037833

http://purl.bioontology.org/ontology/PDQ/CDR0000271916

http://purl.bioontology.org/ontology/PDQ/CDR0000041221

http://purl.bioontology.org/ontology/PDQ/CDR0000042395

http://purl.bioontology.org/ontology/PDQ/CDR0000041930

http://purl.bioontology.org/ontology/PDQ/CDR0000041313

http://purl.bioontology.org/ontology/PDQ/CDR0000041495

http://purl.bioontology.org/ontology/PDQ/CDR0000041494

http://purl.bioontology.org/ontology/PDQ/CDR0000041499

http://purl.bioontology.org/ontology/PDQ/CDR0000043688

http://purl.bioontology.org/ontology/PDQ/CDR0000041315

http://purl.bioontology.org/ontology/PDQ/CDR0000041128

http://purl.bioontology.org/ontology/PDQ/CDR0000041007

http://purl.bioontology.org/ontology/PDQ/CDR0000038850

http://purl.bioontology.org/ontology/PDQ/CDR0000041734

http://purl.bioontology.org/ontology/PDQ/CDR0000040894

http://purl.bioontology.org/ontology/PDQ/CDR0000041464

http://purl.bioontology.org/ontology/PDQ/CDR0000041181

http://purl.bioontology.org/ontology/PDQ/CDR0000042350

http://purl.bioontology.org/ontology/PDQ/CDR0000039384

http://purl.bioontology.org/ontology/PDQ/CDR0000038306

http://purl.bioontology.org/ontology/PDQ/CDR0000038930

http://purl.bioontology.org/ontology/PDQ/CDR0000039036

http://purl.bioontology.org/ontology/PDQ/CDR0000038556

http://purl.bioontology.org/ontology/PDQ/CDR0000042004

http://purl.bioontology.org/ontology/PDQ/CDR0000039664

http://purl.bioontology.org/ontology/PDQ/CDR0000039346

http://purl.bioontology.org/ontology/PDQ/CDR0000040655

http://purl.bioontology.org/ontology/PDQ/CDR0000037832

http://purl.bioontology.org/ontology/PDQ/CDR0000039563

http://purl.bioontology.org/ontology/PDQ/CDR0000038859

http://purl.bioontology.org/ontology/PDQ/CDR0000039777

http://purl.bioontology.org/ontology/PDQ/CDR0000039333

http://purl.bioontology.org/ontology/PDQ/CDR0000041465

http://purl.bioontology.org/ontology/PDQ/CDR0000037835

http://purl.bioontology.org/ontology/PDQ/CDR0000041330

http://purl.bioontology.org/ontology/PDQ/CDR0000041948

http://purl.bioontology.org/ontology/PDQ/CDR0000042097

http://purl.bioontology.org/ontology/PDQ/CDR0000041491

http://purl.bioontology.org/ontology/PDQ/CDR0000038309

http://purl.bioontology.org/ontology/PDQ/CDR0000041329

cui

C0003993

C1522682

C5441916

C1257720

C1257721

C1522681

C1510952

C0699262

C1527242

C4727813

C1510954

Date last modified

2018-03-28

definition

An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C286" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C286" NCI Thesaurus)

Legacy PDQ ID

422

LT

TRD

NCI ID

C286

notation

CDR0000041146

NSC Code

109229

ORIG STY

Drug/agent

prefLabel

asparaginase

tui

T116

T126

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SNOMEDCT/18811003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D001215 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001215 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001215 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001215 MESH CUI
http://purl.bioontology.org/ontology/SNMI/F-6B130 SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/370969007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RCD/XC0Qg RCD CUI
http://purl.bioontology.org/ontology/RXNORM/1156 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/18811003 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D001215 MSHFRE CUI
http://purl.bioontology.org/ontology/VANDF/4017974 VANDF CUI
http://purl.bioontology.org/ontology/ATC/L01XX02 ATC CUI
http://purl.bioontology.org/ontology/SNMI/C-78275 SNMI CUI
http://purl.bioontology.org/ontology/NDDF/002673 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006477 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/371014004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146324 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/371014004 SCTSPA CUI
http://purl.bioontology.org/ontology/RCD/h59.. RCD CUI
http://purl.bioontology.org/ontology/MESH/D001215 MESH CUI
http://purl.bioontology.org/ontology/CSP/0116-0841 CRISP CUI
http://purl.bioontology.org/ontology/SNMI/C-C1820 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/F-6B130 SNMI LOOM
http://purl.bioontology.org/ontology/RXNORM/1156 RXNORM LOOM
http://purl.obolibrary.org/obo/MESH_D001215 BERO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00019296 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/OMIM/618472 OMIM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C286 NCIT LOOM
http://purl.bioontology.org/ontology/VANDF/4017974 VANDF LOOM
http://purl.bioontology.org/ontology/ATC/L01XX02 ATC LOOM
http://purl.obolibrary.org/obo/TXPO_0005181 TXPO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D08.811.277.087.116 RH-MESH LOOM
http://purl.obolibrary.org/obo/NCIT_C286 BERO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D001215 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1513 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/002673 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/371014004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146324 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0003993 OCHV LOOM
http://purl.obolibrary.org/obo/dinto_DB00023 DINTO LOOM
http://purl.bioontology.org/ontology/MESH/D001215 MESH LOOM
http://purl.obolibrary.org/obo/DRON_00013033 PDRO LOOM
http://purl.obolibrary.org/obo/DRON_00013033 DRON LOOM
http://purl.obolibrary.org/obo/OMIT_0002600 OMIT LOOM
http://purl.bioontology.org/ontology/CSP/0116-0841 CRISP LOOM
http://purl.jp/bio/4/id/200906036592562961 IOBC LOOM