loading...| Preferred Name |
diacetylmorphine hydrochloride |
|
| Synonyms |
morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, morphine, Diacetate (ester), hydrochloride |
|
| Definitions |
The hydrochloride salt of a diacetyl derivative of the opiate morphine, a naturally occurring alkaloid extracted from the seedpod of the Asian poppy (Papaver sp.). Once administered, diamorphine (or diacetylmorphine) is rapidly hydrolyzed to 6-monoacetylmorphine (6-MAM) and then to the end-product morphine which binds to opiate receptors located throughout the mammalian nervous and gastrointestinal systems. Inducing a potent analgesia, the use of diamoprhine is often escalated due to a tolerance effect, resulting in abuse that is associated with fatal overdose, abortion, venous sclerosis, and opportunistic infections, among other adverse effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28958" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28958" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040567 |
|
| altLabel |
morphinan-3,6alpha-diol, 7,8-didehydro-4,5alpha-epoxy-17-methyl-, morphine, Diacetate (ester), hydrochloride diamorphine hydrochloride heroin hydrochloride |
|
| cui |
C0282128 |
|
| Date last modified |
2014-08-15 |
|
| definition |
The hydrochloride salt of a diacetyl derivative of the opiate morphine, a naturally occurring alkaloid extracted from the seedpod of the Asian poppy (Papaver sp.). Once administered, diamorphine (or diacetylmorphine) is rapidly hydrolyzed to 6-monoacetylmorphine (6-MAM) and then to the end-product morphine which binds to opiate receptors located throughout the mammalian nervous and gastrointestinal systems. Inducing a potent analgesia, the use of diamoprhine is often escalated due to a tolerance effect, resulting in abuse that is associated with fatal overdose, abortion, venous sclerosis, and opportunistic infections, among other adverse effects. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C28958" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C28958" NCI Thesaurus) |
|
| NCI ID |
C28958 |
|
| notation |
CDR0000040567 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
diacetylmorphine hydrochloride |
|
| tui |
T109 T131 |