sargramostim

DRG-0012

A recombinant therapeutic agent which is chemically identical to or similar to endogenous human GM-CSF. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1492" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1492" NCI Thesaurus)

http://purl.bioontology.org/ontology/PDQ/CDR0000040566

DRG-0012

Prokine

CSF-2

Leukine

granulocyte-macrophage colony stimulating factor

granulocyte-macrophage colony-stimulating factor

granulocyte macrophage colony-stimulating factor

sargramostatin

GM CSF

colony stimulating factor 2

GM-CSF

rhu GM-CFS

23-L-leucine colony-stimulating factor 2

123774-72-1

http://purl.bioontology.org/ontology/PDQ/CDR0000043451

http://purl.bioontology.org/ontology/PDQ/CDR0000037951

http://purl.bioontology.org/ontology/PDQ/CDR0000441036

http://purl.bioontology.org/ontology/PDQ/CDR0000041117

http://purl.bioontology.org/ontology/PDQ/CDR0000039092

http://purl.bioontology.org/ontology/PDQ/CDR0000038313

http://purl.bioontology.org/ontology/PDQ/CDR0000039335

http://purl.bioontology.org/ontology/PDQ/CDR0000038605

http://purl.bioontology.org/ontology/PDQ/CDR0000042030

http://purl.bioontology.org/ontology/PDQ/CDR0000041164

http://purl.bioontology.org/ontology/PDQ/CDR0000039433

http://purl.bioontology.org/ontology/PDQ/CDR0000043610

http://purl.bioontology.org/ontology/PDQ/CDR0000042549

http://purl.bioontology.org/ontology/PDQ/CDR0000043039

http://purl.bioontology.org/ontology/PDQ/CDR0000037799

http://purl.bioontology.org/ontology/PDQ/CDR0000043614

http://purl.bioontology.org/ontology/PDQ/CDR0000041368

http://purl.bioontology.org/ontology/PDQ/CDR0000039093

http://purl.bioontology.org/ontology/PDQ/CDR0000042986

http://purl.bioontology.org/ontology/PDQ/CDR0000269485

http://purl.bioontology.org/ontology/PDQ/CDR0000434553

http://purl.bioontology.org/ontology/PDQ/CDR0000269239

http://purl.bioontology.org/ontology/PDQ/CDR0000041476

http://purl.bioontology.org/ontology/PDQ/CDR0000038544

http://purl.bioontology.org/ontology/PDQ/CDR0000041173

http://purl.bioontology.org/ontology/PDQ/CDR0000039439

http://purl.bioontology.org/ontology/PDQ/CDR0000038687

http://purl.bioontology.org/ontology/PDQ/CDR0000043152

http://purl.bioontology.org/ontology/PDQ/CDR0000042890

http://purl.bioontology.org/ontology/PDQ/CDR0000038061

http://purl.bioontology.org/ontology/PDQ/CDR0000041240

http://purl.bioontology.org/ontology/PDQ/CDR0000041062

http://purl.bioontology.org/ontology/PDQ/CDR0000039095

http://purl.bioontology.org/ontology/PDQ/CDR0000039453

http://purl.bioontology.org/ontology/PDQ/CDR0000305936

http://purl.bioontology.org/ontology/PDQ/CDR0000042028

http://purl.bioontology.org/ontology/PDQ/CDR0000040589

http://purl.bioontology.org/ontology/PDQ/CDR0000042597

http://purl.bioontology.org/ontology/PDQ/CDR0000042988

http://purl.bioontology.org/ontology/PDQ/CDR0000043212

http://purl.bioontology.org/ontology/PDQ/CDR0000038499

http://purl.bioontology.org/ontology/PDQ/CDR0000042094

http://purl.bioontology.org/ontology/PDQ/CDR0000042880

http://purl.bioontology.org/ontology/PDQ/CDR0000043601

http://purl.bioontology.org/ontology/PDQ/CDR0000434552

http://purl.bioontology.org/ontology/PDQ/CDR0000043656

http://purl.bioontology.org/ontology/PDQ/CDR0000041430

http://purl.bioontology.org/ontology/PDQ/CDR0000043634

http://purl.bioontology.org/ontology/PDQ/CDR0000039438

http://purl.bioontology.org/ontology/PDQ/CDR0000043608

http://purl.bioontology.org/ontology/PDQ/CDR0000038081

http://purl.bioontology.org/ontology/PDQ/CDR0000385669

http://purl.bioontology.org/ontology/PDQ/CDR0000042101

http://purl.bioontology.org/ontology/PDQ/CDR0000038220

http://purl.bioontology.org/ontology/PDQ/CDR0000043248

http://purl.bioontology.org/ontology/PDQ/CDR0000387974

http://purl.bioontology.org/ontology/PDQ/CDR0000038339

http://purl.bioontology.org/ontology/PDQ/CDR0000039448

http://purl.bioontology.org/ontology/PDQ/CDR0000038971

http://purl.bioontology.org/ontology/PDQ/CDR0000041343

http://purl.bioontology.org/ontology/PDQ/CDR0000041869

http://purl.bioontology.org/ontology/PDQ/CDR0000357442

http://purl.bioontology.org/ontology/PDQ/CDR0000039681

http://purl.bioontology.org/ontology/PDQ/CDR0000041416

http://purl.bioontology.org/ontology/PDQ/CDR0000428223

http://purl.bioontology.org/ontology/PDQ/CDR0000276473

http://purl.bioontology.org/ontology/PDQ/CDR0000038116

http://purl.bioontology.org/ontology/PDQ/CDR0000039412

http://purl.bioontology.org/ontology/PDQ/CDR0000041788

http://purl.bioontology.org/ontology/PDQ/CDR0000042165

http://purl.bioontology.org/ontology/PDQ/CDR0000042972

http://purl.bioontology.org/ontology/PDQ/CDR0000043618

http://purl.bioontology.org/ontology/PDQ/CDR0000039452

http://purl.bioontology.org/ontology/PDQ/CDR0000391279

http://purl.bioontology.org/ontology/PDQ/CDR0000038238

http://purl.bioontology.org/ontology/PDQ/CDR0000040582

http://purl.bioontology.org/ontology/PDQ/CDR0000038681

http://purl.bioontology.org/ontology/PDQ/CDR0000042284

http://purl.bioontology.org/ontology/PDQ/CDR0000039366

http://purl.bioontology.org/ontology/PDQ/CDR0000043040

http://purl.bioontology.org/ontology/PDQ/CDR0000269493

http://purl.bioontology.org/ontology/PDQ/CDR0000380925

http://purl.bioontology.org/ontology/PDQ/CDR0000041374

http://purl.bioontology.org/ontology/PDQ/CDR0000339875

http://purl.bioontology.org/ontology/PDQ/CDR0000341634

http://purl.bioontology.org/ontology/PDQ/CDR0000041161

http://purl.bioontology.org/ontology/PDQ/CDR0000038576

http://purl.bioontology.org/ontology/PDQ/CDR0000039616

http://purl.bioontology.org/ontology/PDQ/CDR0000428320

http://purl.bioontology.org/ontology/PDQ/CDR0000041063

http://purl.bioontology.org/ontology/PDQ/CDR0000041030

http://purl.bioontology.org/ontology/PDQ/CDR0000042031

http://purl.bioontology.org/ontology/PDQ/CDR0000041093

http://purl.bioontology.org/ontology/PDQ/CDR0000269066

http://purl.bioontology.org/ontology/PDQ/CDR0000039111

http://purl.bioontology.org/ontology/PDQ/CDR0000042156

http://purl.bioontology.org/ontology/PDQ/CDR0000042313

http://purl.bioontology.org/ontology/PDQ/CDR0000041448

http://purl.bioontology.org/ontology/PDQ/CDR0000038470

http://purl.bioontology.org/ontology/PDQ/CDR0000039442

http://purl.bioontology.org/ontology/PDQ/CDR0000038639

http://purl.bioontology.org/ontology/PDQ/CDR0000040821

http://purl.bioontology.org/ontology/PDQ/CDR0000041155

http://purl.bioontology.org/ontology/PDQ/CDR0000043518

http://purl.bioontology.org/ontology/PDQ/CDR0000380733

http://purl.bioontology.org/ontology/PDQ/CDR0000434536

http://purl.bioontology.org/ontology/PDQ/CDR0000041099

http://purl.bioontology.org/ontology/PDQ/CDR0000041981

http://purl.bioontology.org/ontology/PDQ/CDR0000043158

http://purl.bioontology.org/ontology/PDQ/CDR0000355823

http://purl.bioontology.org/ontology/PDQ/CDR0000315587

http://purl.bioontology.org/ontology/PDQ/CDR0000039457

http://purl.bioontology.org/ontology/PDQ/CDR0000304353

http://purl.bioontology.org/ontology/PDQ/CDR0000042557

http://purl.bioontology.org/ontology/PDQ/CDR0000039447

http://purl.bioontology.org/ontology/PDQ/CDR0000385668

http://purl.bioontology.org/ontology/PDQ/CDR0000043621

http://purl.bioontology.org/ontology/PDQ/CDR0000041370

http://purl.bioontology.org/ontology/PDQ/CDR0000041160

http://purl.bioontology.org/ontology/PDQ/CDR0000041172

http://purl.bioontology.org/ontology/PDQ/CDR0000038982

http://purl.bioontology.org/ontology/PDQ/CDR0000341636

http://purl.bioontology.org/ontology/PDQ/CDR0000041177

http://purl.bioontology.org/ontology/PDQ/CDR0000041302

http://purl.bioontology.org/ontology/PDQ/CDR0000380852

http://purl.bioontology.org/ontology/PDQ/CDR0000037938

http://purl.bioontology.org/ontology/PDQ/CDR0000039619

http://purl.bioontology.org/ontology/PDQ/CDR0000043091

http://purl.bioontology.org/ontology/PDQ/CDR0000041116

http://purl.bioontology.org/ontology/PDQ/CDR0000038356

http://purl.bioontology.org/ontology/PDQ/CDR0000041280

http://purl.bioontology.org/ontology/PDQ/CDR0000341635

http://purl.bioontology.org/ontology/PDQ/CDR0000039112

http://purl.bioontology.org/ontology/PDQ/CDR0000038651

http://purl.bioontology.org/ontology/PDQ/CDR0000257388

http://purl.bioontology.org/ontology/PDQ/CDR0000041261

http://purl.bioontology.org/ontology/PDQ/CDR0000257383

http://purl.bioontology.org/ontology/PDQ/CDR0000041976

http://purl.bioontology.org/ontology/PDQ/CDR0000043598

http://purl.bioontology.org/ontology/PDQ/CDR0000038386

http://purl.bioontology.org/ontology/PDQ/CDR0000380749

http://purl.bioontology.org/ontology/PDQ/CDR0000038561

http://purl.bioontology.org/ontology/PDQ/CDR0000039664

http://purl.bioontology.org/ontology/PDQ/CDR0000041220

http://purl.bioontology.org/ontology/PDQ/CDR0000039626

http://purl.bioontology.org/ontology/PDQ/CDR0000041442

http://purl.bioontology.org/ontology/PDQ/CDR0000042895

http://purl.bioontology.org/ontology/PDQ/CDR0000043555

http://purl.bioontology.org/ontology/PDQ/CDR0000041454

http://purl.bioontology.org/ontology/PDQ/CDR0000039102

http://purl.bioontology.org/ontology/PDQ/CDR0000039107

http://purl.bioontology.org/ontology/PDQ/CDR0000043653

http://purl.bioontology.org/ontology/PDQ/CDR0000042891

http://purl.bioontology.org/ontology/PDQ/CDR0000037881

http://purl.bioontology.org/ontology/PDQ/CDR0000043233

http://purl.bioontology.org/ontology/PDQ/CDR0000038580

http://purl.bioontology.org/ontology/PDQ/CDR0000341637

http://purl.bioontology.org/ontology/PDQ/CDR0000041322

http://purl.bioontology.org/ontology/PDQ/CDR0000436113

http://purl.bioontology.org/ontology/PDQ/CDR0000043628

http://purl.bioontology.org/ontology/PDQ/CDR0000380927

http://purl.bioontology.org/ontology/PDQ/CDR0000041796

http://purl.bioontology.org/ontology/PDQ/CDR0000038495

C0701499

C2709280

C0216231

C0701500

C0079460

2017-11-21

A recombinant therapeutic agent which is chemically identical to or similar to endogenous human GM-CSF. Binding to specific cell surface receptors, sargramostim modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function; it may also augment host antitumoral immunity. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1492" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1492" NCI Thesaurus)

3465

TRD

C1492

CDR0000040566

Drug/agent

sargramostim

T116

T129

T121