Preferred Name |
ganciclovir |
|
Synonyms |
2'NDG |
|
Definitions |
A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C517" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C517" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040565 |
|
altLabel |
2'NDG 2'-Nor-2'-deoxyguanosine Cymevan BW-B 759U 2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one Nordeoxyguanosine 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine BW 759U DHPG Virgan BW-B759U |
|
CAS Registry |
82410-32-0 |
|
Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000038069 |
|
cui |
C0701310 C0701311 C0017066 C1517438 C1517437 |
|
Date last modified |
2006-08-07 |
|
definition |
A synthetic guanine derivative with antiviral activity. As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C517" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C517" NCI Thesaurus) |
|
Legacy PDQ ID |
3464 |
|
LT |
TRD |
|
NCI ID |
C517 |
|
notation |
CDR0000040565 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
ganciclovir |
|
tui |
T114 T121 |