loading...| Preferred Name |
ibuprofen |
|
| Synonyms |
p-isobutylhydratropic acid |
|
| Definitions |
A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C561" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C561" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040475 |
|
| altLabel |
p-isobutylhydratropic acid benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)- Motrin |
|
| CAS Registry |
15687-27-1 |
|
| cui |
C0699203 C0020740 |
|
| definition |
A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C561" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C561" NCI Thesaurus) |
|
| Legacy PDQ ID |
3359 |
|
| LT |
TRD |
|
| NCI ID |
C561 |
|
| notation |
CDR0000040475 |
|
| NSC Code |
256857 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
ibuprofen |
|
| tui |
T109 T121 |