Preferred Name |
zalcitabine |
|
Synonyms |
Hivid |
|
Definitions |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C430" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C430" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040349 |
|
altLabel |
Hivid 2',3'-dideoxycytidine ddC dideoxycytidine |
|
CAS Registry |
7481-89-2 |
|
Component of | ||
cui |
C0012132 C0678123 |
|
definition |
A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C430" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C430" NCI Thesaurus) |
|
IND Code |
33134 28975 30858 |
|
Legacy PDQ ID |
3201 |
|
LT |
TRD |
|
NCI ID |
C430 |
|
notation |
CDR0000040349 |
|
NSC Code |
606170 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
zalcitabine |
|
tui |
T114 T121 |