Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

dapsone

Synonyms

sulfona-mae

Definitions

A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C415" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C415" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000040323

altLabel

sulfona-mae

4,4'-sulfonylbisbenzeneamine

DADPS

croysulfone

Undolac

dumitone

Avlosulfon

DDS

novophone

bis(4-aminophenyl)sulfone

1358F

sulphadione

4,4'-sulfonylbisbenzamine

Eporal

4,4'-sulfonyldianiline

Aczone

Disulone

diphenasone

CAS Registry

80-08-0

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000039388

cui

C1527112

C1511722

C0729116

C1511721

C0010980

C1652085

C1511723

Date last modified

2017-04-05

definition

A synthetic derivative of diamino-sulfone with anti-inflammatory and anti-bacterial properties. As a structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Although the exact mechanism through which dapsone exerts its anti-inflammatory activity has yet to be fully elucidated, this agent interferes with the activation and oxidative damage of myeloperoxidase in neutrophils and inhibits the integrin-mediated adherence and chemotaxis of neutrophils. Dapsone's anti-inflammatory activities may contribute to the effects seen upon topical administration. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C415" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C415" NCI Thesaurus)

Legacy PDQ ID

3165

LT

TRD

NCI ID

C415

notation

CDR0000040323

NSC Code

6091

ORIG STY

Drug/agent

prefLabel

dapsone

tui

T109

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/MESH/D003622 MESH CUI
http://purl.bioontology.org/ontology/CSP/2840-6854 CRISP CUI
http://purl.bioontology.org/ontology/RXNORM/605173 RXNORM CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387096002 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDDF/003003 NDDF CUI
http://purl.bioontology.org/ontology/ATC/J04BA02 ATC CUI
http://purl.bioontology.org/ontology/MESH/D003622 MESH CUI
http://purl.bioontology.org/ontology/SCTSPA/387096002 SCTSPA CUI
http://purl.bioontology.org/ontology/MSHFRE/D003622 MSHFRE CUI
http://purl.bioontology.org/ontology/LNC/MTHU024811 LOINC CUI
http://purl.bioontology.org/ontology/SNMI/C-55292 SNMI CUI
http://purl.bioontology.org/ontology/ATC/D10AX05 ATC CUI
http://purl.bioontology.org/ontology/LNC/LP32038-9 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000006908 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4019264 VANDF CUI
http://purl.bioontology.org/ontology/RXNORM/3108 RXNORM CUI
http://purl.bioontology.org/ontology/LNC/LP17991-8 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/17308007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/17308007 SCTSPA CUI
http://purl.bioontology.org/ontology/RCD/ee1.. RCD CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147467 NDFRT CUI
https://github.com/sap218/coid/blob/master/coid.owl#COID_00897 COID LOOM
http://purl.bioontology.org/ontology/CSP/2840-6854 CRISP LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387096002 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003622 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/003003 NDDF LOOM
http://purl.bioontology.org/ontology/ATC/J04BA02 ATC LOOM
http://purl.obolibrary.org/obo/MESH_D003622 BERO LOOM
http://purl.jp/bio/4/id/200906089537092065 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D003622 MESH LOOM
http://www.co-ode.org/ontologies/galen#Dapsone GALEN LOOM
http://purl.obolibrary.org/obo/CHEBI_4325 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_4325 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_4325 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_4325 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_4325 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_4325 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_4325 ODNAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.263 RH-MESH LOOM
http://purl.obolibrary.org/obo/ARO_3003412 ARO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU024811 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C415 BERO LOOM
http://purl.bioontology.org/ontology/SNMI/C-55292 SNMI LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017418 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/ATC/D10AX05 ATC LOOM
http://scai.fraunhofer.de/AlzheimerOntology#Dapsone ADO LOOM
http://purl.bioontology.org/ontology/LNC/LP32038-9 LOINC LOOM
http://purl.obolibrary.org/obo/OMIT_0004905 OMIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0010980 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C415 NCIT LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147467 ODAE LOOM
http://purl.bioontology.org/ontology/VANDF/4019264 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/3108 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP17991-8 LOINC LOOM
https://go.drugbank.com/drugs/DB00250 MDM LOOM
http://purl.bioontology.org/ontology/RCD/ee1.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147467 NDFRT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3609 OCHV LOOM