loading...| Preferred Name |
leuprolide acetate |
|
| Synonyms |
leuprorelin acetate |
|
| Definitions |
The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1319" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1319" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000040058 |
|
| altLabel |
leuprorelin acetate Prostap Procrin Eligard DWJ108J Depo-Eligard TAP-144 Uno-Enantone Enantone 6-D-leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing hormone-releasing factor (pig) monoacetate LEUP Lucrin Leuplin 6-D-leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide luteinizing hormone-releasing factor (pig) monoacetate Lucrin Depot Ginecrin Enanton Carcinil Procren Lupron Abbott-43818 Trenantone Lupron Depot Enantone-Gyn Abbott 43818 A-43818 |
|
| CAS Registry |
74381-53-6 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041483 http://purl.bioontology.org/ontology/PDQ/CDR0000041292 http://purl.bioontology.org/ontology/PDQ/CDR0000041183 http://purl.bioontology.org/ontology/PDQ/CDR0000410698 http://purl.bioontology.org/ontology/PDQ/CDR0000357873 http://purl.bioontology.org/ontology/PDQ/CDR0000041521 http://purl.bioontology.org/ontology/PDQ/CDR0000041303 http://purl.bioontology.org/ontology/PDQ/CDR0000410696 http://purl.bioontology.org/ontology/PDQ/CDR0000041519 http://purl.bioontology.org/ontology/PDQ/CDR0000041769 http://purl.bioontology.org/ontology/PDQ/CDR0000041776 http://purl.bioontology.org/ontology/PDQ/CDR0000362078 http://purl.bioontology.org/ontology/PDQ/CDR0000041775 http://purl.bioontology.org/ontology/PDQ/CDR0000334947 http://purl.bioontology.org/ontology/PDQ/CDR0000358327 http://purl.bioontology.org/ontology/PDQ/CDR0000042915 http://purl.bioontology.org/ontology/PDQ/CDR0000042092 http://purl.bioontology.org/ontology/PDQ/CDR0000042089 http://purl.bioontology.org/ontology/PDQ/CDR0000362084 http://purl.bioontology.org/ontology/PDQ/CDR0000358058 http://purl.bioontology.org/ontology/PDQ/CDR0000042090 |
|
| cui |
C1170247 C1517831 C0701461 C0701459 C1517834 C0700596 C0086550 C1517836 C0085272 C1517833 C1517839 C1517840 C0701460 C4732949 C1517838 C1517830 C3642287 C1517841 C0524775 C1517835 C1517837 |
|
| Date last modified |
2018-06-05 |
|
| definition |
The acetate salt of a synthetic nonapeptide analogue of gonadotropin-releasing hormone. Leuprolide binds to and activates gonadotropin-releasing hormone (GnRH) receptors. Continuous, prolonged administration of leuprolide in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. This agent reduces testosterone production to castration levels and may inhibit androgen receptor-positive tumor progression. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1319" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1319" NCI Thesaurus) |
|
| Legacy PDQ ID |
2798 |
|
| LT |
TRD |
|
| NCI ID |
C1319 |
|
| notation |
CDR0000040058 |
|
| NSC Code |
377526 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
leuprolide acetate |
|
| tui |
T125 T109 T116 T121 |