Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

ifosfamide

Synonyms

Ifex

Definitions

A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40024&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40024&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C564" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000040024

altLabel

Ifex

3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide

Ifolem

Iphosphamid

Isoendoxan

Holoxan

Iso-Endoxan

IFO

2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine

MJF-9325

IPP

Holoxane

Ifomide

IFO-Cell

Ifoxan

IFX

Ifosfamidum

IFF

Mitoxana

Ifomida

N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

isophosphamide

Cyfos

Naxamide

iphosphamide

Tronoxal

Asta Z-4942

Z-4942

CAS Registry

3778-73-2

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041983

http://purl.bioontology.org/ontology/PDQ/CDR0000042655

http://purl.bioontology.org/ontology/PDQ/CDR0000040464

http://purl.bioontology.org/ontology/PDQ/CDR0000041094

http://purl.bioontology.org/ontology/PDQ/CDR0000041917

http://purl.bioontology.org/ontology/PDQ/CDR0000038434

http://purl.bioontology.org/ontology/PDQ/CDR0000038871

http://purl.bioontology.org/ontology/PDQ/CDR0000039367

http://purl.bioontology.org/ontology/PDQ/CDR0000041734

http://purl.bioontology.org/ontology/PDQ/CDR0000043150

http://purl.bioontology.org/ontology/PDQ/CDR0000038669

http://purl.bioontology.org/ontology/PDQ/CDR0000039315

http://purl.bioontology.org/ontology/PDQ/CDR0000041864

http://purl.bioontology.org/ontology/PDQ/CDR0000041906

http://purl.bioontology.org/ontology/PDQ/CDR0000373889

http://purl.bioontology.org/ontology/PDQ/CDR0000041979

http://purl.bioontology.org/ontology/PDQ/CDR0000373941

http://purl.bioontology.org/ontology/PDQ/CDR0000042087

http://purl.bioontology.org/ontology/PDQ/CDR0000042064

http://purl.bioontology.org/ontology/PDQ/CDR0000042081

http://purl.bioontology.org/ontology/PDQ/CDR0000039782

http://purl.bioontology.org/ontology/PDQ/CDR0000042645

http://purl.bioontology.org/ontology/PDQ/CDR0000038863

http://purl.bioontology.org/ontology/PDQ/CDR0000039102

http://purl.bioontology.org/ontology/PDQ/CDR0000042025

http://purl.bioontology.org/ontology/PDQ/CDR0000041934

http://purl.bioontology.org/ontology/PDQ/CDR0000306473

http://purl.bioontology.org/ontology/PDQ/CDR0000038982

http://purl.bioontology.org/ontology/PDQ/CDR0000038131

http://purl.bioontology.org/ontology/PDQ/CDR0000041160

http://purl.bioontology.org/ontology/PDQ/CDR0000037772

http://purl.bioontology.org/ontology/PDQ/CDR0000041100

http://purl.bioontology.org/ontology/PDQ/CDR0000041009

http://purl.bioontology.org/ontology/PDQ/CDR0000361785

http://purl.bioontology.org/ontology/PDQ/CDR0000042548

http://purl.bioontology.org/ontology/PDQ/CDR0000038449

http://purl.bioontology.org/ontology/PDQ/CDR0000040998

http://purl.bioontology.org/ontology/PDQ/CDR0000041805

http://purl.bioontology.org/ontology/PDQ/CDR0000038436

http://purl.bioontology.org/ontology/PDQ/CDR0000041691

http://purl.bioontology.org/ontology/PDQ/CDR0000040414

http://purl.bioontology.org/ontology/PDQ/CDR0000037781

http://purl.bioontology.org/ontology/PDQ/CDR0000041980

http://purl.bioontology.org/ontology/PDQ/CDR0000040801

http://purl.bioontology.org/ontology/PDQ/CDR0000042518

http://purl.bioontology.org/ontology/PDQ/CDR0000042646

http://purl.bioontology.org/ontology/PDQ/CDR0000041968

http://purl.bioontology.org/ontology/PDQ/CDR0000041649

http://purl.bioontology.org/ontology/PDQ/CDR0000042080

http://purl.bioontology.org/ontology/PDQ/CDR0000038396

http://purl.bioontology.org/ontology/PDQ/CDR0000042552

http://purl.bioontology.org/ontology/PDQ/CDR0000038964

http://purl.bioontology.org/ontology/PDQ/CDR0000039342

http://purl.bioontology.org/ontology/PDQ/CDR0000042241

http://purl.bioontology.org/ontology/PDQ/CDR0000040508

http://purl.bioontology.org/ontology/PDQ/CDR0000358902

http://purl.bioontology.org/ontology/PDQ/CDR0000041942

http://purl.bioontology.org/ontology/PDQ/CDR0000039104

http://purl.bioontology.org/ontology/PDQ/CDR0000041955

http://purl.bioontology.org/ontology/PDQ/CDR0000041085

http://purl.bioontology.org/ontology/PDQ/CDR0000038630

http://purl.bioontology.org/ontology/PDQ/CDR0000038292

http://purl.bioontology.org/ontology/PDQ/CDR0000037924

http://purl.bioontology.org/ontology/PDQ/CDR0000037875

http://purl.bioontology.org/ontology/PDQ/CDR0000040804

http://purl.bioontology.org/ontology/PDQ/CDR0000042636

http://purl.bioontology.org/ontology/PDQ/CDR0000039458

http://purl.bioontology.org/ontology/PDQ/CDR0000042463

http://purl.bioontology.org/ontology/PDQ/CDR0000038539

http://purl.bioontology.org/ontology/PDQ/CDR0000041819

http://purl.bioontology.org/ontology/PDQ/CDR0000041453

http://purl.bioontology.org/ontology/PDQ/CDR0000042172

http://purl.bioontology.org/ontology/PDQ/CDR0000042046

http://purl.bioontology.org/ontology/PDQ/CDR0000041507

http://purl.bioontology.org/ontology/PDQ/CDR0000041609

http://purl.bioontology.org/ontology/PDQ/CDR0000042174

http://purl.bioontology.org/ontology/PDQ/CDR0000041423

http://purl.bioontology.org/ontology/PDQ/CDR0000042053

http://purl.bioontology.org/ontology/PDQ/CDR0000038337

http://purl.bioontology.org/ontology/PDQ/CDR0000038482

http://purl.bioontology.org/ontology/PDQ/CDR0000039569

http://purl.bioontology.org/ontology/PDQ/CDR0000041907

http://purl.bioontology.org/ontology/PDQ/CDR0000038018

http://purl.bioontology.org/ontology/PDQ/CDR0000042794

http://purl.bioontology.org/ontology/PDQ/CDR0000042656

http://purl.bioontology.org/ontology/PDQ/CDR0000041156

http://purl.bioontology.org/ontology/PDQ/CDR0000299571

http://purl.bioontology.org/ontology/PDQ/CDR0000041035

http://purl.bioontology.org/ontology/PDQ/CDR0000041288

http://purl.bioontology.org/ontology/PDQ/CDR0000039380

http://purl.bioontology.org/ontology/PDQ/CDR0000041635

http://purl.bioontology.org/ontology/PDQ/CDR0000041888

http://purl.bioontology.org/ontology/PDQ/CDR0000039103

http://purl.bioontology.org/ontology/PDQ/CDR0000041597

http://purl.bioontology.org/ontology/PDQ/CDR0000039341

http://purl.bioontology.org/ontology/PDQ/CDR0000039111

http://purl.bioontology.org/ontology/PDQ/CDR0000445422

http://purl.bioontology.org/ontology/PDQ/CDR0000358901

http://purl.bioontology.org/ontology/PDQ/CDR0000041302

http://purl.bioontology.org/ontology/PDQ/CDR0000038442

http://purl.bioontology.org/ontology/PDQ/CDR0000040898

http://purl.bioontology.org/ontology/PDQ/CDR0000041593

http://purl.bioontology.org/ontology/PDQ/CDR0000043321

http://purl.bioontology.org/ontology/PDQ/CDR0000038120

http://purl.bioontology.org/ontology/PDQ/CDR0000040882

http://purl.bioontology.org/ontology/PDQ/CDR0000041448

http://purl.bioontology.org/ontology/PDQ/CDR0000039346

http://purl.bioontology.org/ontology/PDQ/CDR0000041369

http://purl.bioontology.org/ontology/PDQ/CDR0000041359

http://purl.bioontology.org/ontology/PDQ/CDR0000039316

http://purl.bioontology.org/ontology/PDQ/CDR0000042803

http://purl.bioontology.org/ontology/PDQ/CDR0000042524

http://purl.bioontology.org/ontology/PDQ/CDR0000038217

http://purl.bioontology.org/ontology/PDQ/CDR0000042171

http://purl.bioontology.org/ontology/PDQ/CDR0000041527

http://purl.bioontology.org/ontology/PDQ/CDR0000039452

http://purl.bioontology.org/ontology/PDQ/CDR0000039110

http://purl.bioontology.org/ontology/PDQ/CDR0000041931

http://purl.bioontology.org/ontology/PDQ/CDR0000042959

http://purl.bioontology.org/ontology/PDQ/CDR0000040255

http://purl.bioontology.org/ontology/PDQ/CDR0000040472

http://purl.bioontology.org/ontology/PDQ/CDR0000038730

http://purl.bioontology.org/ontology/PDQ/CDR0000042389

http://purl.bioontology.org/ontology/PDQ/CDR0000041791

http://purl.bioontology.org/ontology/PDQ/CDR0000043537

http://purl.bioontology.org/ontology/PDQ/CDR0000042549

http://purl.bioontology.org/ontology/PDQ/CDR0000041161

http://purl.bioontology.org/ontology/PDQ/CDR0000422413

http://purl.bioontology.org/ontology/PDQ/CDR0000041749

http://purl.bioontology.org/ontology/PDQ/CDR0000041736

http://purl.bioontology.org/ontology/PDQ/CDR0000042065

cui

C1512621

C1522402

C1512617

C1704313

C0733930

C0733929

C1512622

C1522401

C1512618

C0721031

C0020823

C0591812

C1512620

C1512619

definition

A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40024&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40024&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C564" NCI Thesaurus)

IND Code

7887

Legacy PDQ ID

275

LT

TRD

NCI ID

C564

notation

CDR0000040024

NSC Code

109724

ORIG STY

Drug/agent

prefLabel

ifosfamide

tui

T109

T121

T114

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/SCTSPA/386904003 SCTSPA CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007069 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/5657 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/5657 RXNORM LOOM
http://purl.bioontology.org/ontology/LNC/LP65841-6 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP65841-6 LOINC LOOM
http://purl.jp/bio/4/id/200906013041937026 IOBC LOOM
http://purl.bioontology.org/ontology/UATC/L01AA06 ATC CUI
http://purl.bioontology.org/ontology/UATC/L01AA06 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4019476 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4019476 VANDF LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.672.500.243.250 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Ifosfamide GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108757000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108757000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147596 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147596 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP65832-5 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP65832-5 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C564 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C564 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C564 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C564 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C564 NCIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.526.728.650.730.243.250 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/x02jY RCD CUI
http://purl.bioontology.org/ontology/NDDF/002642 NDDF CUI
http://purl.bioontology.org/ontology/RCD/h17.. RCD CUI
http://purl.bioontology.org/ontology/RCD/h17.. RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.533.500 RH-MESH LOOM
http://www.ifomis.org/acgt/1.0#Ifosfamide ACGT-MO LOOM
http://doe-generated-ontology.com/OntoPneumo#Ifosfamide ONTOPNEUMO LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_5864 CHEBI LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386904003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386904003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MSHFRE/D007069 MSHFRE CUI
http://purl.bioontology.org/ontology/RXNORM/217701 RXNORM CUI
http://purl.bioontology.org/ontology/MESH/D007069 MESH CUI
http://purl.bioontology.org/ontology/MESH/D007069 MESH CUI
http://purl.bioontology.org/ontology/MESH/D007069 MESH CUI
http://purl.bioontology.org/ontology/MESH/D007069 MESH LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000007045 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/108757000 SCTSPA CUI
http://purl.bioontology.org/ontology/CSP/4000-0210 CRISP CUI
http://purl.bioontology.org/ontology/CSP/4000-0210 CRISP LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147596 ODAE LOOM