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Last uploaded: January 31, 2024

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Preferred Name	ifosfamide
Synonyms	2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine
Definitions	A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C564" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C564" NCI Thesaurus)
ID	http://purl.bioontology.org/ontology/PDQ/CDR0000040024
altLabel	2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine IFO Iphosphamid Holoxane N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide Ifex IPP Ifomide Tronoxal Ifoxan Mitoxana Asta Z-4942 IFF Naxamide Z-4942 iphosphamide 3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide Iso-Endoxan Ifolem Isoendoxan IFO-Cell MJF-9325 Holoxan isophosphamide Ifomida IFX
CAS Registry	3778-73-2
Component of	http://purl.bioontology.org/ontology/PDQ/CDR0000042081 http://purl.bioontology.org/ontology/PDQ/CDR0000041864 http://purl.bioontology.org/ontology/PDQ/CDR0000041819 http://purl.bioontology.org/ontology/PDQ/CDR0000041507 http://purl.bioontology.org/ontology/PDQ/CDR0000043150 http://purl.bioontology.org/ontology/PDQ/CDR0000041369 http://purl.bioontology.org/ontology/PDQ/CDR0000042656 http://purl.bioontology.org/ontology/PDQ/CDR0000042549 http://purl.bioontology.org/ontology/PDQ/CDR0000041980 http://purl.bioontology.org/ontology/PDQ/CDR0000041009 http://purl.bioontology.org/ontology/PDQ/CDR0000040508 http://purl.bioontology.org/ontology/PDQ/CDR0000038436 http://purl.bioontology.org/ontology/PDQ/CDR0000042552 http://purl.bioontology.org/ontology/PDQ/CDR0000037781 http://purl.bioontology.org/ontology/PDQ/CDR0000041597 http://purl.bioontology.org/ontology/PDQ/CDR0000041691 http://purl.bioontology.org/ontology/PDQ/CDR0000361785 http://purl.bioontology.org/ontology/PDQ/CDR0000042046 http://purl.bioontology.org/ontology/PDQ/CDR0000042389 http://purl.bioontology.org/ontology/PDQ/CDR0000041423 http://purl.bioontology.org/ontology/PDQ/CDR0000042645 http://purl.bioontology.org/ontology/PDQ/CDR0000299571 http://purl.bioontology.org/ontology/PDQ/CDR0000039782 http://purl.bioontology.org/ontology/PDQ/CDR0000041736 http://purl.bioontology.org/ontology/PDQ/CDR0000040898 http://purl.bioontology.org/ontology/PDQ/CDR0000373941 http://purl.bioontology.org/ontology/PDQ/CDR0000038730 http://purl.bioontology.org/ontology/PDQ/CDR0000039380 http://purl.bioontology.org/ontology/PDQ/CDR0000043537 http://purl.bioontology.org/ontology/PDQ/CDR0000042655 http://purl.bioontology.org/ontology/PDQ/CDR0000039367 http://purl.bioontology.org/ontology/PDQ/CDR0000039341 http://purl.bioontology.org/ontology/PDQ/CDR0000358901 http://purl.bioontology.org/ontology/PDQ/CDR0000041791 http://purl.bioontology.org/ontology/PDQ/CDR0000041906 http://purl.bioontology.org/ontology/PDQ/CDR0000038292 http://purl.bioontology.org/ontology/PDQ/CDR0000041609 http://purl.bioontology.org/ontology/PDQ/CDR0000042518 http://purl.bioontology.org/ontology/PDQ/CDR0000042959 http://purl.bioontology.org/ontology/PDQ/CDR0000040804 http://purl.bioontology.org/ontology/PDQ/CDR0000039569 http://purl.bioontology.org/ontology/PDQ/CDR0000358902 http://purl.bioontology.org/ontology/PDQ/CDR0000042636 http://purl.bioontology.org/ontology/PDQ/CDR0000039103 http://purl.bioontology.org/ontology/PDQ/CDR0000041527 http://purl.bioontology.org/ontology/PDQ/CDR0000041917 http://purl.bioontology.org/ontology/PDQ/CDR0000040414 http://purl.bioontology.org/ontology/PDQ/CDR0000042171 http://purl.bioontology.org/ontology/PDQ/CDR0000039104 http://purl.bioontology.org/ontology/PDQ/CDR0000041983 http://purl.bioontology.org/ontology/PDQ/CDR0000037924 http://purl.bioontology.org/ontology/PDQ/CDR0000038396 http://purl.bioontology.org/ontology/PDQ/CDR0000041094 http://purl.bioontology.org/ontology/PDQ/CDR0000042080 http://purl.bioontology.org/ontology/PDQ/CDR0000041359 http://purl.bioontology.org/ontology/PDQ/CDR0000042065 http://purl.bioontology.org/ontology/PDQ/CDR0000042548 http://purl.bioontology.org/ontology/PDQ/CDR0000039110 http://purl.bioontology.org/ontology/PDQ/CDR0000040464 http://purl.bioontology.org/ontology/PDQ/CDR0000042172 http://purl.bioontology.org/ontology/PDQ/CDR0000038863 http://purl.bioontology.org/ontology/PDQ/CDR0000039452 http://purl.bioontology.org/ontology/PDQ/CDR0000041931 http://purl.bioontology.org/ontology/PDQ/CDR0000042524 http://purl.bioontology.org/ontology/PDQ/CDR0000041805 http://purl.bioontology.org/ontology/PDQ/CDR0000042646 http://purl.bioontology.org/ontology/PDQ/CDR0000041749 http://purl.bioontology.org/ontology/PDQ/CDR0000042064 http://purl.bioontology.org/ontology/PDQ/CDR0000041968 http://purl.bioontology.org/ontology/PDQ/CDR0000041161 http://purl.bioontology.org/ontology/PDQ/CDR0000373889 http://purl.bioontology.org/ontology/PDQ/CDR0000041934 http://purl.bioontology.org/ontology/PDQ/CDR0000039111 http://purl.bioontology.org/ontology/PDQ/CDR0000041448 http://purl.bioontology.org/ontology/PDQ/CDR0000039458 http://purl.bioontology.org/ontology/PDQ/CDR0000038442 http://purl.bioontology.org/ontology/PDQ/CDR0000042794 http://purl.bioontology.org/ontology/PDQ/CDR0000040472 http://purl.bioontology.org/ontology/PDQ/CDR0000306473 http://purl.bioontology.org/ontology/PDQ/CDR0000041979 http://purl.bioontology.org/ontology/PDQ/CDR0000038018 http://purl.bioontology.org/ontology/PDQ/CDR0000038871 http://purl.bioontology.org/ontology/PDQ/CDR0000042053 http://purl.bioontology.org/ontology/PDQ/CDR0000040882 http://purl.bioontology.org/ontology/PDQ/CDR0000041160 http://purl.bioontology.org/ontology/PDQ/CDR0000038982 http://purl.bioontology.org/ontology/PDQ/CDR0000040255 http://purl.bioontology.org/ontology/PDQ/CDR0000037875 http://purl.bioontology.org/ontology/PDQ/CDR0000041955 http://purl.bioontology.org/ontology/PDQ/CDR0000445422 http://purl.bioontology.org/ontology/PDQ/CDR0000040801 http://purl.bioontology.org/ontology/PDQ/CDR0000039315 http://purl.bioontology.org/ontology/PDQ/CDR0000041302 http://purl.bioontology.org/ontology/PDQ/CDR0000043321 http://purl.bioontology.org/ontology/PDQ/CDR0000041453 http://purl.bioontology.org/ontology/PDQ/CDR0000039342 http://purl.bioontology.org/ontology/PDQ/CDR0000037772 http://purl.bioontology.org/ontology/PDQ/CDR0000038630 http://purl.bioontology.org/ontology/PDQ/CDR0000038337 http://purl.bioontology.org/ontology/PDQ/CDR0000041942 http://purl.bioontology.org/ontology/PDQ/CDR0000041100 http://purl.bioontology.org/ontology/PDQ/CDR0000041734 http://purl.bioontology.org/ontology/PDQ/CDR0000038449 http://purl.bioontology.org/ontology/PDQ/CDR0000038217 http://purl.bioontology.org/ontology/PDQ/CDR0000042087 http://purl.bioontology.org/ontology/PDQ/CDR0000039316 http://purl.bioontology.org/ontology/PDQ/CDR0000042241 http://purl.bioontology.org/ontology/PDQ/CDR0000041888 http://purl.bioontology.org/ontology/PDQ/CDR0000041035 http://purl.bioontology.org/ontology/PDQ/CDR0000038539 http://purl.bioontology.org/ontology/PDQ/CDR0000038964 http://purl.bioontology.org/ontology/PDQ/CDR0000041156 http://purl.bioontology.org/ontology/PDQ/CDR0000041907 http://purl.bioontology.org/ontology/PDQ/CDR0000038120 http://purl.bioontology.org/ontology/PDQ/CDR0000039346 http://purl.bioontology.org/ontology/PDQ/CDR0000042463 http://purl.bioontology.org/ontology/PDQ/CDR0000042803 http://purl.bioontology.org/ontology/PDQ/CDR0000039102 http://purl.bioontology.org/ontology/PDQ/CDR0000041593 http://purl.bioontology.org/ontology/PDQ/CDR0000038434 http://purl.bioontology.org/ontology/PDQ/CDR0000038131 http://purl.bioontology.org/ontology/PDQ/CDR0000042174 http://purl.bioontology.org/ontology/PDQ/CDR0000041085 http://purl.bioontology.org/ontology/PDQ/CDR0000042025 http://purl.bioontology.org/ontology/PDQ/CDR0000040998 http://purl.bioontology.org/ontology/PDQ/CDR0000038482 http://purl.bioontology.org/ontology/PDQ/CDR0000038669 http://purl.bioontology.org/ontology/PDQ/CDR0000422413 http://purl.bioontology.org/ontology/PDQ/CDR0000041635 http://purl.bioontology.org/ontology/PDQ/CDR0000041649 http://purl.bioontology.org/ontology/PDQ/CDR0000041288
cui	C1512618 C0020823 C0733930 C0591812 C1512622 C0721031 C1512620 C0733929 C1522402 C1512619 C1512621 C1522401 C1512617
Date last modified	2018-02-13
definition	A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication. This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C564" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C564" NCI Thesaurus)
IND Code	7887
Legacy PDQ ID	275
LT	TRD
NCI ID	C564
notation	CDR0000040024
NSC Code	109724
ORIG STY	Drug/agent
prefLabel	ifosfamide
tui	T109 T114 T121

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/SCTSPA/386904003	SCTSPA	CUI
http://purl.bioontology.org/ontology/MESH/D007069	MESH	CUI
http://purl.bioontology.org/ontology/RCD/x02jY	RCD	CUI
http://purl.bioontology.org/ontology/RXNORM/217701	RXNORM	CUI
http://purl.bioontology.org/ontology/MESH/D007069	MESH	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147596	NDFRT	CUI
http://purl.bioontology.org/ontology/MESH/D007069	MESH	CUI
http://purl.bioontology.org/ontology/VANDF/4019476	VANDF	CUI
http://purl.bioontology.org/ontology/RCD/h17..	RCD	CUI
http://purl.bioontology.org/ontology/MSHFRE/D007069	MSHFRE	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/386904003	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/RXNORM/5657	RXNORM	CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108757000	SNOMEDCT	CUI
http://purl.bioontology.org/ontology/SCTSPA/108757000	SCTSPA	CUI
http://purl.bioontology.org/ontology/NDFRT/N0000007045	NDFRT	CUI
http://purl.bioontology.org/ontology/CSP/4000-0210	CRISP	CUI
http://purl.bioontology.org/ontology/LNC/LP65832-5	LOINC	CUI
http://purl.bioontology.org/ontology/LNC/LP65841-6	LOINC	CUI
http://purl.bioontology.org/ontology/NDDF/002642	NDDF	CUI
http://purl.bioontology.org/ontology/ATC/L01AA06	ATC	CUI
http://purl.obolibrary.org/obo/CHEBI_5864	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5864	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5864	DINTO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5864	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5864	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_5864	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_5864	ODNAE	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147596	NDFRT	LOOM
http://purl.bioontology.org/ontology/MESH/D007069	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007069	RH-MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4019476	VANDF	LOOM
http://www.ifomis.org/acgt/1.0#Ifosfamide	ACGT-MO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017037	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RCD/h17..	RCD	LOOM
http://purl.obolibrary.org/obo/OMIT_0008200	OMIT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386904003	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/RXNORM/5657	RXNORM	LOOM
http://purl.obolibrary.org/obo/NCIT_C564	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.526.728.650.730.243.250	RH-MESH	LOOM
http://purl.bioontology.org/ontology/CSP/4000-0210	CRISP	LOOM
http://purl.bioontology.org/ontology/LNC/LP65832-5	LOINC	LOOM
http://purl.bioontology.org/ontology/LNC/LP65841-6	LOINC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.533.500	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Ifosfamide	GALEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#6537	OCHV	LOOM
https://go.drugbank.com/drugs/DB01181	MDM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.705.672.500.243.250	RH-MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C564	NCIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0020823	OCHV	LOOM
http://purl.jp/bio/4/id/200906013041937026	IOBC	LOOM
http://doe-generated-ontology.com/OntoPneumo#Ifosfamide	ONTOPNEUMO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147596	ODAE	LOOM
http://purl.obolibrary.org/obo/MESH_D007069	BERO	LOOM
http://stirdf.jst.go.jp/id/200907032215822116	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/L01AA06	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_5864	CHEBI	LOOM