Preferred Name |
nabilone |
|
Synonyms |
Cesamet |
|
Definitions |
A synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity. Although the mechanism of action has not been fully elucidated yet, it has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1171" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1171" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039760 |
|
altLabel |
Cesamet Cpd 109514 |
|
CAS Registry |
56496-90-3 |
|
cui |
C0969772 C0068333 C1263104 |
|
definition |
A synthetic cannabinoid and dibenzopyrane derivative with anti-emetic activity. Although the mechanism of action has not been fully elucidated yet, it has been suggested that nabilone is a highly selective and strong agonist for the cannabinoid receptors CB1 and CB2, both of which are coupled to Gi/o proteins. The CB1 receptors are expressed predominantly in central and peripheral neurons and receptor stimulation has been implicated in the reduction of chemotherapy-induced nausea. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1171" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1171" NCI Thesaurus) |
|
Legacy PDQ ID |
2422 |
|
LT |
TRD |
|
NCI ID |
C1171 |
|
notation |
CDR0000039760 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
nabilone |
|
tui |
T109 T121 |