loading...| Preferred Name |
mesna |
|
| Synonyms |
Mistabronco |
|
| Definitions |
A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C192" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C192" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039759 |
|
| altLabel |
Mistabronco Mesnum Mucofluid Mucolene Ziken mercaptoethane sulfonate mercaptoethanesulfonate 2-mercaptoethanesulfonic acid, sodium salt Ausobronc Mesnex Mitexan Mesnil Sodium 2-Mercaptoethanesulphonate sodium 2-mercaptoethane sulfonate Mistabron Uromitexan D-7093 MSA Filesna UCB 3983 Mexan |
|
| CAS Registry |
19767-45-4 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000042656 http://purl.bioontology.org/ontology/PDQ/CDR0000042616 http://purl.bioontology.org/ontology/PDQ/CDR0000042389 http://purl.bioontology.org/ontology/PDQ/CDR0000042645 http://purl.bioontology.org/ontology/PDQ/CDR0000042655 http://purl.bioontology.org/ontology/PDQ/CDR0000042636 http://purl.bioontology.org/ontology/PDQ/CDR0000042646 |
|
| cui |
C1513147 C1513150 C0721681 C1513154 C1513153 C0733875 C0678115 C1513149 C0733874 C1521833 C0733876 C5441835 C0085721 C0000294 C1513148 |
|
| Date last modified |
2006-08-29 |
|
| definition |
A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C192" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C192" NCI Thesaurus) |
|
| IND Code |
25232 |
|
| Legacy PDQ ID |
2420 |
|
| LT |
TRD |
|
| NCI ID |
C192 |
|
| notation |
CDR0000039759 |
|
| NSC Code |
113891 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
mesna |
|
| tui |
T109 T121 |