Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

lorazepam

Synonyms

Ativan

Definitions

A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C619" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039757

altLabel

Ativan

7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one

CAS Registry

846-49-1

cui

C0699194

C0024002

definition

A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39757&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C619" NCI Thesaurus)

Legacy PDQ ID

2418

LT

TRD

NCI ID

C619

notation

CDR0000039757

NSC Code

289758

ORIG STY

Drug/agent

prefLabel

lorazepam

tui

T109

T121

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C619 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C619 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C619 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C619 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/202479 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/387106007 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-64570 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-64570 SNMI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000007094 NDFRT CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008140 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6470 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/6470 RXNORM LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_27cf392c_3718_428f_97e8_ad9b74d413b1 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_27cf392c_3718_428f_97e8_ad9b74d413b1 STO-DRAFT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003365 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU003365 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Lorazepam GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/19225000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/19225000 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MESH/D008140 MESH CUI
http://purl.bioontology.org/ontology/MESH/D008140 MESH CUI
http://purl.bioontology.org/ontology/MESH/D008140 MESH LOOM
http://purl.jp/bio/4/id/200906081111062834 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/001460 NDDF CUI
http://purl.bioontology.org/ontology/MSHFRE/D008140 MSHFRE CUI
http://www.limics.fr/ontologies/ontoparonmed#Lorazepam ONTOPARON LOOM
http://www.limics.fr/ontologies/ontoparonmed#Lorazepam ONTOPARON LOOM
http://www.drugbank.ca/drugs/DB00186 FTC LOOM
http://bmi.utah.edu/ontologies/hfontology/C0024002 HFO LOOM
http://www.case.edu/EpSO.owl#Lorazepam EPSO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387106007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387106007 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RCD/x02Ui RCD CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.079.080.070.450 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_6539 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6539 NBO LOOM
http://purl.bioontology.org/ontology/LNC/LP16176-7 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP16176-7 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/0314-5650 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0314-5650 CRISP LOOM
http://purl.bioontology.org/ontology/SCTSPA/19225000 SCTSPA CUI
http://purl.bioontology.org/ontology/UATC/N05BA06 ATC CUI
http://purl.bioontology.org/ontology/UATC/N05BA06 ATC LOOM
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http://purl.bioontology.org/ontology/RCD/x02LN RCD LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Lorazepam APAONTO LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#lorazepam SDO LOOM
http://purl.bioontology.org/ontology/VANDF/4017848 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017848 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146205 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146205 NDFRT LOOM