loading...| Preferred Name |
tobramycin sulfate |
|
| Synonyms |
Tobrex |
|
| Definitions |
The sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and fixes the 30 S-50 S ribosomal complex at the start codon (AUG), interfering with the initiation of protein synthesis. In addition, this agent induces misreading of the mRNA template, which results in 1) detachment of the ribosomal complex and inhibition of protein elongation or 2) incorporation of the incorrect amino acids into the growing polypeptide chain and the production of abnormal or nonfunctional proteins. Altogether, cell permeability is altered and cell death ensues. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C893" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C893" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039727 |
|
| altLabel |
Tobrex |
|
| CAS Registry |
49842-07-1 |
|
| Component of | ||
| cui |
C0027519 C0723768 |
|
| Date last modified |
2017-11-02 |
|
| definition |
The sulfate salt of tobramycin, an aminoglycoside antibiotic derived from the bacterium Streptomyces tenebrarius with bactericidal activity. Following active transport into the cell, tobramycin binds irreversibly to a specific aminoglycoside receptor on the bacterial 30S ribosomal subunit and fixes the 30 S-50 S ribosomal complex at the start codon (AUG), interfering with the initiation of protein synthesis. In addition, this agent induces misreading of the mRNA template, which results in 1) detachment of the ribosomal complex and inhibition of protein elongation or 2) incorporation of the incorrect amino acids into the growing polypeptide chain and the production of abnormal or nonfunctional proteins. Altogether, cell permeability is altered and cell death ensues. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C893" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C893" NCI Thesaurus) |
|
| Legacy PDQ ID |
2389 |
|
| LT |
TRD |
|
| NCI ID |
C893 |
|
| notation |
CDR0000039727 |
|
| NSC Code |
180514 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
tobramycin sulfate |
|
| tui |
T109 T195 |