Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

prochlorperazine

Synonyms

Prochlorperazine Maleate

Definitions

The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C775" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C775" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039564

altLabel

Prochlorperazine Maleate

prochlorperazine dimaleate

Compazine

CAS Registry

84-02-6

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041151

http://purl.bioontology.org/ontology/PDQ/CDR0000042514

cui

C0033229

C0033231

C0701017

Date last modified

2017-11-02

definition

The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C775" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C775" NCI Thesaurus)

Legacy PDQ ID

2218

NCI ID

C775

notation

CDR0000039564

NSC Code

17478

ORIG STY

Drug/agent

prefLabel

prochlorperazine

tui

T109

T121

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http://purl.bioontology.org/ontology/NDFRT/N0000005824 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4018000 VANDF CUI
http://purl.bioontology.org/ontology/MESH/D011346 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/79129001 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D011346 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D011346 MESH CUI
http://purl.bioontology.org/ontology/LNC/MTHU036745 LOINC CUI
http://purl.bioontology.org/ontology/VANDF/4018001 VANDF CUI
http://purl.bioontology.org/ontology/ATC/N05AB04 ATC CUI
http://purl.bioontology.org/ontology/SNMI/C-62A40 SNMI CUI
http://purl.bioontology.org/ontology/LNC/LP102316-9 LOINC CUI
http://purl.bioontology.org/ontology/RXNORM/8704 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/79129001 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146346 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/372853006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RCD/x02LV RCD CUI
http://purl.bioontology.org/ontology/CSP/2264-5872 CRISP CUI
http://purl.bioontology.org/ontology/SCTSPA/372853006 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/001478 NDDF CUI
http://purl.bioontology.org/ontology/MSHFRE/D011346 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D011346 MESH CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146345 NDFRT CUI
http://purl.bioontology.org/ontology/SNMI/C-62A42 SNMI CUI
http://purl.bioontology.org/ontology/SNOMEDCT/22827004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/NDDF/001480 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000178962 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/22827004 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/8706 RXNORM CUI
http://purl.bioontology.org/ontology/SNMI/C-62A40 SNMI CUI
http://purl.bioontology.org/ontology/RXNORM/203546 RXNORM CUI
http://purl.obolibrary.org/obo/CHEBI_8435 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_8435 CHEBI LOOM
http://www.case.edu/EpilepsyOntology.owl#Prochlorperazine EPSO LOOM
http://purl.obolibrary.org/obo/OMIT_0012302 OMIT LOOM
http://purl.bioontology.org/ontology/MESH/D011346 MESH LOOM
http://www.case.edu/EpSO.owl#Prochlorperazine MEPO LOOM
http://purl.bioontology.org/ontology/LNC/MTHU036745 LOINC LOOM
http://purl.bioontology.org/ontology/VANDF/4018001 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#10141 OCHV LOOM
http://purl.bioontology.org/ontology/ATC/N05AB04 ATC LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017401 PMAPP-PMO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.369.639 RH-MESH LOOM
http://purl.jp/bio/4/id/200906045183227254 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.494.741.639 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNMI/C-62A40 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/LP102316-9 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C774 NCIT LOOM
http://purl.obolibrary.org/obo/NCIT_C774 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8435 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_8435 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_8435 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_8435 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_8435 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_8435 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_8435 NIFSTD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D011346 RH-MESH LOOM
http://purl.obolibrary.org/obo/MESH_D011346 BERO LOOM
https://go.drugbank.com/drugs/DB00433 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/8704 RXNORM LOOM
http://scai.fraunhofer.de/AlzheimerOntology#prochlorperazine ADO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146346 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372853006 SNOMEDCT LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Prochlorperazine APAONTO LOOM
http://stirdf.jst.go.jp/id/200907058186669884 IOBC LOOM
http://purl.bioontology.org/ontology/RCD/x02LV RCD LOOM
http://purl.bioontology.org/ontology/CSP/2264-5872 CRISP LOOM
http://www.drugbank.ca/drugs/DB00433 FTC LOOM
http://www.co-ode.org/ontologies/galen#Prochlorperazine GALEN LOOM
http://purl.bioontology.org/ontology/NDDF/001478 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0033229 OCHV LOOM