Preferred Name |
prochlorperazine |
|
Synonyms |
Prochlorperazine Maleate |
|
Definitions |
The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C775" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C775" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039564 |
|
altLabel |
Prochlorperazine Maleate prochlorperazine dimaleate Compazine |
|
CAS Registry |
84-02-6 |
|
Component of | ||
cui |
C0033229 C0033231 C0701017 |
|
Date last modified |
2017-11-02 |
|
definition |
The maleate salt form of prochlorperazine, a synthetic, piperazine phenothiazine derivative with antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Prochlorperazine binds to and blocks the postsynaptic dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. Prochlorperazine maleate also blocks anticholinergic and alpha-adrenergic receptors. Its antagonistic actions on the alpha-1 adrenergic receptors results in sedation, muscle relaxation, and hypotension. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C775" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C775" NCI Thesaurus) |
|
Legacy PDQ ID |
2218 |
|
NCI ID |
C775 |
|
notation |
CDR0000039564 |
|
NSC Code |
17478 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
prochlorperazine |
|
tui |
T109 T121 |