loading...| Preferred Name |
pentamethylmelamine |
|
| Synonyms |
PMM |
|
| Definitions |
A principal metabolite of hexamethylmelamine with antineoplastic activity. Pentamethylmelamine alkylates DNA and other macromolecules and forms DNA intrastrand and DNA-protein crosslinks, thereby preventing DNA replication. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1189" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1189" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039553 |
|
| altLabel |
PMM N,N,N',N',N"-pentamethyl-1,3,5-triazine |
|
| CAS Registry |
16268-62-5 |
|
| cui |
C0070302 |
|
| Date last modified |
2008-10-06 |
|
| definition |
A principal metabolite of hexamethylmelamine with antineoplastic activity. Pentamethylmelamine alkylates DNA and other macromolecules and forms DNA intrastrand and DNA-protein crosslinks, thereby preventing DNA replication. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1189" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1189" NCI Thesaurus) |
|
| IND Code |
14585 |
|
| Legacy PDQ ID |
2202 |
|
| NCI ID |
C1189 |
|
| notation |
CDR0000039553 |
|
| NSC Code |
118742 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
pentamethylmelamine |
|
| tui |
T109 T121 |