loading...| Preferred Name |
naloxone hydrochloride |
|
| Synonyms |
Narcan |
|
| Definitions |
The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity. Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. This agent binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C678" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C678" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039509 |
|
| altLabel |
Narcan |
|
| CAS Registry |
357-08-4 |
|
| cui |
C0684237 C0700549 |
|
| Date last modified |
2017-11-02 |
|
| definition |
The hydrochloride salt of naloxone, a thebaine derivate with opioid antagonist activity. Naloxone binds to opioid receptors in the CNS in a competitive manner, reversing or inhibiting characteristic opioid effects, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. This agent binds to mu-opioid receptors with a high affinity, and a lesser degree to kappa- and gamma-opioid receptors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C678" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C678" NCI Thesaurus) |
|
| Legacy PDQ ID |
2143 |
|
| LT |
TRD |
|
| NCI ID |
C678 |
|
| notation |
CDR0000039509 |
|
| NSC Code |
70413 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
naloxone hydrochloride |
|
| tui |
T109 T121 |