Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

metronidazole hydrochloride

Synonyms

Satric

Definitions

The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48005" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48005" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039503

altLabel

Satric

Flagyl

SC 32642

CAS Registry

69198-10-3

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041455

http://purl.bioontology.org/ontology/PDQ/CDR0000041459

http://purl.bioontology.org/ontology/PDQ/CDR0000041458

http://purl.bioontology.org/ontology/PDQ/CDR0000041456

http://purl.bioontology.org/ontology/PDQ/CDR0000041460

http://purl.bioontology.org/ontology/PDQ/CDR0000041457

http://purl.bioontology.org/ontology/PDQ/CDR0000042882

cui

C0699678

C0699684

C2919050

C0282239

Date last modified

2017-11-02

definition

The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48005" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48005" NCI Thesaurus)

Legacy PDQ ID

2137

LT

TRD

NCI ID

C48005

notation

CDR0000039503

ORIG STY

Drug/agent

prefLabel

metronidazole hydrochloride

tui

T109

T121

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http://purl.bioontology.org/ontology/RCD/x02ci RCD CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48005 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C48005 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/82047 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/82047 RXNORM LOOM
http://purl.bioontology.org/ontology/MSHFRE/D008795 MSHFRE CUI
http://purl.bioontology.org/ontology/SNMI/C-52041 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-52041 SNMI LOOM
http://purl.bioontology.org/ontology/VANDF/4017837 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017837 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146195 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146195 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_50687 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_50687 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_50687 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_50687 CHEBI LOOM
http://purl.bioontology.org/ontology/RXNORM/202866 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/002959 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/3941003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/3941003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000179428 NDFRT CUI
http://purl.bioontology.org/ontology/SCTSPA/3941003 SCTSPA CUI
http://purl.bioontology.org/ontology/MESH/D008795 MESH CUI
http://purl.bioontology.org/ontology/MESH/D008795 MESH CUI
http://purl.bioontology.org/ontology/MESH/D008795 MESH CUI