loading...| Preferred Name |
metronidazole |
| Synonyms |
Satric |
| Definitions |
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39503&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39503&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C651" NCI Thesaurus) |
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039503 |
| altLabel |
Satric METRO Flagyl Metro I.V. |
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041455 http://purl.bioontology.org/ontology/PDQ/CDR0000041459 http://purl.bioontology.org/ontology/PDQ/CDR0000041458 http://purl.bioontology.org/ontology/PDQ/CDR0000041456 http://purl.bioontology.org/ontology/PDQ/CDR0000041460 |
| cui |
C0699675 C0699678 C0699684 C0025872 |
| Date last modified |
2006-07-20 |
| definition |
A synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39503&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39503&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C651" NCI Thesaurus) |
| Legacy PDQ ID |
2137 |
| LT |
TRD |
| NCI ID |
C651 |
| notation |
CDR0000039503 |
| ORIG STY |
Drug/agent |
| prefLabel |
metronidazole |
| tui |
T109 T121 |