loading...| Preferred Name |
metronidazole hydrochloride |
| Synonyms |
Satric |
| Definitions |
The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48005" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48005" NCI Thesaurus) |
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039503 |
| altLabel |
Satric Flagyl SC 32642 |
| CAS Registry |
69198-10-3 |
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041455 http://purl.bioontology.org/ontology/PDQ/CDR0000041459 http://purl.bioontology.org/ontology/PDQ/CDR0000041458 http://purl.bioontology.org/ontology/PDQ/CDR0000041456 http://purl.bioontology.org/ontology/PDQ/CDR0000041460 |
| cui |
C0699678 C0699684 C2919050 C0282239 |
| Date last modified |
2017-11-02 |
| definition |
The hydrochloride salt of a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities. Although its mechanism of action is not fully elucidated, un-ionized metronidazole is readily taken up by obligate anaerobic organisms and is subsequently reduced by low-redox potential electron-transport proteins to an active, intermediate product. Reduced metronidazole causes DNA strand breaks, thereby inhibiting DNA synthesis and bacterial cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C48005" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C48005" NCI Thesaurus) |
| Legacy PDQ ID |
2137 |
| LT |
TRD |
| NCI ID |
C48005 |
| notation |
CDR0000039503 |
| ORIG STY |
Drug/agent |
| prefLabel |
metronidazole hydrochloride |
| tui |
T109 T121 |