Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

metoclopramide hydrochloride

Synonyms

Reglan

Definitions

The hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2 (D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C649" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C649" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039502

altLabel

Reglan

CAS Registry

7232-21-5

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000042990

http://purl.bioontology.org/ontology/PDQ/CDR0000041059

cui

C0034977

C0887128

Date last modified

2017-11-02

definition

The hydrochloride salt of the substituted benzamide metoclopramide, a para-aminobenzoic acid (PABA) derivative that is structurally related to procainamide, with gastroprokinetic and antiemetic activities. Metoclopramide binds to dopamine 2 (D2) receptors in the peripheral nervous system (PNS), antagonizing dopamine-mediated relaxation of gastrointestinal smooth muscle and promoting gastroprokinesis; the pyloric sphincter and the duodenal bulb are relaxed, peristalsis of the duodenum and jejunum increase, and gastric emptying and intestinal transit accelerate. This agent may also increase the resting tone of the lower esophagus sphincter (LES), preventing acid reflux. In the central nervous system (CNS), metoclopramide antagonizes D2 dopamine receptors in the chemoreceptive trigger zone (CTZ) of the medulla, thereby preventing nausea and vomiting. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C649" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C649" NCI Thesaurus)

Legacy PDQ ID

2136

LT

TRD

NCI ID

C649

notation

CDR0000039502

NSC Code

354467

ORIG STY

Drug/agent

prefLabel

metoclopramide hydrochloride

tui

T109

T121

Delete Subject Author Type Created
No notes to display