loading...| Preferred Name |
monobenzone |
|
| Synonyms |
Benoquin |
|
| Definitions |
A monobenzyl ether of hydroquinone with topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of monobenzone appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C992" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C992" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039494 |
|
| altLabel |
Benoquin MBEH monobenzyl ether of hydroquinone |
|
| CAS Registry |
103-16-2 |
|
| cui |
C0050962 C0718893 |
|
| definition |
A monobenzyl ether of hydroquinone with topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of monobenzone appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C992" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C992" NCI Thesaurus) |
|
| Legacy PDQ ID |
2127 |
|
| LT |
TRD |
|
| NCI ID |
C992 |
|
| notation |
CDR0000039494 |
|
| NSC Code |
33918 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
monobenzone |
|
| tui |
T109 T121 |