Preferred Name |
lithium carbonate |
|
Synonyms |
Lithium |
|
Definitions |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stemcells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1318" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1318" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039491 |
|
altLabel |
Lithium Lithane Lithotabs Lithonate Eskalith Lithobid |
|
cui |
C0700752 C0700750 C0023870 C0700189 C0700751 C0085217 C0700753 |
|
Date last modified |
2008-02-15 |
|
definition |
The carbonate salt of lithium, a soft alkali metal, with antimanic and hematopoietic activities. Lithium interferes with transmembrane sodium exchange in nerve cells by affecting sodium, potassium-stimulated adenosine triphosphatase (Na+, K+-ATPase); alters the release of neurotransmitters; affects cyclic adenosine monophosphate (cAMP) concentrations; and blocks inositol metabolism resulting in depletion of cellular inositol and inhibition of phospholipase C-mediated signal transduction. The exact mechanism through which lithium exerts its mood-stabilizing effect has not been established. In addition, lithium stimulates granulocytopoiesis and appears to increase the level of pluripotent hematopoietic stem cells by stimulating the release of hematopoietic cytokines and/or directly acting on hematopoietic stemcells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1318" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1318" NCI Thesaurus) |
|
Legacy PDQ ID |
2124 |
|
LT |
TRD |
|
NCI ID |
C1318 |
|
notation |
CDR0000039491 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
lithium carbonate |
|
tui |
T197 T109 T196 T121 |