Physician Data Query

Last uploaded: April 29, 2019
Preferred Name

indomethacin

Synonyms

INDO

Definitions

A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39489&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39489&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C576" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039489

altLabel

INDO

Indocin

Indometacin

1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid

CAS Registry

53-86-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041251

http://purl.bioontology.org/ontology/PDQ/CDR0000041543

http://purl.bioontology.org/ontology/PDQ/CDR0000042558

http://purl.bioontology.org/ontology/PDQ/CDR0000042188

http://purl.bioontology.org/ontology/PDQ/CDR0000041943

http://purl.bioontology.org/ontology/PDQ/CDR0000041944

http://purl.bioontology.org/ontology/PDQ/CDR0000039081

cui

C0021246

C0700798

Date last modified

2006-08-28

definition

A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug (NSAID), indomethacin inhibits the enzyme cyclooxygenase, thereby preventing cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines. This agent also may inhibit the expression of multidrug-resistant protein type 1, resulting in increased efficacies of some antineoplastic agents in treating multi-drug resistant tumors. In addition, indomethacin activates phosphatases that inhibit the migration and proliferation of cancer cells and downregulates survivin, which may result in tumor cell apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39489&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39489&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C576" NCI Thesaurus)

Legacy PDQ ID

2122

LT

TRD

NCI ID

C576

notation

CDR0000039489

NSC Code

77541

ORIG STY

Drug/agent

prefLabel

indomethacin

tui

T109

T121

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http://www.semanticweb.org/ontologies/STO.owl#OWLClass_260075c7_2b00_4492_8a93_67c969917236 CVAO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_260075c7_2b00_4492_8a93_67c969917236 STO-DRAFT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C576 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C576 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C576 NCIT LOOM
http://purl.bioontology.org/ontology/RCD/j29.. RCD CUI
http://purl.bioontology.org/ontology/LNC/LP16167-6 LOINC CUI
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http://purl.bioontology.org/ontology/UATC/C01EB03 ATC CUI
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http://id.loc.gov/authorities/subjects/sh85065731 FAST-TOPICAL LOOM
http://doe-generated-ontology.com/OntoAD#C0021246 ONTOAD LOOM
http://purl.bioontology.org/ontology/UATC/S01BC01 ATC CUI
http://purl.jp/bio/4/id/200906019882637637 IOBC LOOM
http://purl.bioontology.org/ontology/SNMI/C-603D0 SNMI CUI
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http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007213 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Indomethacin GALEN LOOM
http://purl.bioontology.org/ontology/UATC/M02AA23 ATC CUI
http://stirdf.jst.go.jp/id/200907082679323667 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373513008 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/373513008 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/002373 NDDF CUI
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http://purl.bioontology.org/ontology/NDFRT/N0000146243 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146243 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/60149003 SNOMEDCT CUI
http://www.drugbank.ca/drugs/DB00328 FTC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU016716 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU016716 LOINC LOOM
http://purl.bioontology.org/ontology/RXNORM/203365 RXNORM CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.473.420 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 ODNAE LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_49662 EFO LOOM
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http://scai.fraunhofer.de/AlzheimerOntology#Indomethacin ADO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000006990 NDFRT CUI