Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

ketoconazole

Synonyms

Nizoral

Definitions

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C605" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C605" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039488

altLabel

Nizoral

Fungarest

KCZ

Ketoderm

Fungoral

Panfungol

Xolegel

cis-1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine

R-41400

Orifungal M

Ketoisdin

CAS Registry

65277-42-1

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000394171

http://purl.bioontology.org/ontology/PDQ/CDR0000363904

http://purl.bioontology.org/ontology/PDQ/CDR0000043415

http://purl.bioontology.org/ontology/PDQ/CDR0000041522

http://purl.bioontology.org/ontology/PDQ/CDR0000038668

http://purl.bioontology.org/ontology/PDQ/CDR0000041459

http://purl.bioontology.org/ontology/PDQ/CDR0000041777

http://purl.bioontology.org/ontology/PDQ/CDR0000042201

http://purl.bioontology.org/ontology/PDQ/CDR0000041458

http://purl.bioontology.org/ontology/PDQ/CDR0000041456

http://purl.bioontology.org/ontology/PDQ/CDR0000041460

http://purl.bioontology.org/ontology/PDQ/CDR0000042809

http://purl.bioontology.org/ontology/PDQ/CDR0000043006

http://purl.bioontology.org/ontology/PDQ/CDR0000042292

http://purl.bioontology.org/ontology/PDQ/CDR0000038119

http://purl.bioontology.org/ontology/PDQ/CDR0000363905

http://purl.bioontology.org/ontology/PDQ/CDR0000041457

http://purl.bioontology.org/ontology/PDQ/CDR0000041521

cui

C0701304

C1517669

C1739451

C1517666

C0022625

C1517670

C0699439

C1517668

C1517671

C1517667

Date last modified

2008-10-06

definition

A synthetic derivative of phenylpiperazine with broad antifungal properties and potential antineoplastic activity. Ketoconazole inhibits sterol 14-a-dimethylase, a microsomal cytochrome P450-dependent enzyme, thereby disrupting synthesis of ergosterol, an important component of the fungal cell wall. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C605" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C605" NCI Thesaurus)

Legacy PDQ ID

2121

LT

TRD

NCI ID

C605

notation

CDR0000039488

NSC Code

317629

ORIG STY

Drug/agent

prefLabel

ketoconazole

tui

T109

T195

T121

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http://purl.bioontology.org/ontology/SNOMEDCT/387216007 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387216007 SNOMEDCT LOOM
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http://purl.bioontology.org/ontology/UATC/J02AB02 ATC LOOM
http://purl.bioontology.org/ontology/UATC/G01AF11 ATC CUI
http://purl.bioontology.org/ontology/UATC/G01AF11 ATC LOOM
http://purl.bioontology.org/ontology/MSHFRE/D007654 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D007654 MSHFRE CUI
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http://purl.obolibrary.org/obo/CHEBI_47519 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_47519 TXPO LOOM
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http://purl.bioontology.org/ontology/MESH/D007654 MESH CUI
http://purl.bioontology.org/ontology/MESH/D007654 MESH CUI
http://purl.bioontology.org/ontology/MESH/D007654 MESH LOOM
http://purl.jp/bio/4/id/200906042931697847 IOBC LOOM
http://purl.obolibrary.org/obo/dinto_DB01026 DINTO LOOM
http://purl.bioontology.org/ontology/RCD/x02l1 RCD CUI
http://stirdf.jst.go.jp/id/200907037443118773 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.606.560 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/202692 RXNORM CUI
http://purl.bioontology.org/ontology/LNC/LP15862-3 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP15862-3 LOINC LOOM
http://purl.bioontology.org/ontology/CSP/1549-4550 CRISP CUI
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http://purl.bioontology.org/ontology/CSP/1549-4550 CRISP LOOM
http://purl.bioontology.org/ontology/SCTSPA/40232005 SCTSPA CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C605 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/647366 RXNORM CUI
http://purl.bioontology.org/ontology/SNMI/C-52B50 SNMI CUI
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http://purl.obolibrary.org/obo/CHEBI_48339 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_48339 DIDEO LOOM
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http://purl.bioontology.org/ontology/UATC/D01AC08 ATC LOOM
http://www.bioassayontology.org/bao#BAO_0000796 BAO LOOM
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http://purl.bioontology.org/ontology/VANDF/4019271 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000007319 NDFRT CUI
http://www.co-ode.org/ontologies/galen#Ketoconazole GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/40232005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SCTSPA/387216007 SCTSPA CUI
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http://purl.bioontology.org/ontology/NDFRT/N0000147470 NDFRT LOOM