Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

isoniazid

Synonyms

isonicotinyl hydrazine

Definitions

A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39484&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39484&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C600" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039484

altLabel

isonicotinyl hydrazine

INH

isonicotinic acid hydrazide

CAS Registry

54-85-3

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041515

cui

C0022209

Date last modified

2006-12-14

definition

A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39484&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39484&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C600" NCI Thesaurus)

Legacy PDQ ID

2118

NCI ID

C600

notation

CDR0000039484

NSC Code

9659

ORIG STY

Drug/agent

prefLabel

isoniazid

tui

T109

T121

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http://purl.bioontology.org/ontology/SNMI/C-55260 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-55260 SNMI LOOM
http://purl.bioontology.org/ontology/LNC/MTHU008094 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU008094 LOINC LOOM
http://www.co-ode.org/ontologies/galen#Isoniazid GALEN LOOM
http://scai.fraunhofer.de/HuPSON#SCAIVPH_00001317 HUPSON LOOM
http://ontology.apa.org/apaonto/termsonlyOUT%20(5).owl#Isoniazid APAONTO LOOM
http://purl.bioontology.org/ontology/SCTSPA/81335000 SCTSPA CUI
http://purl.bioontology.org/ontology/RCD/ed4.. RCD CUI
http://purl.bioontology.org/ontology/RCD/ed4.. RCD LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000006318 NDFRT CUI
http://purl.bioontology.org/ontology/VANDF/4017505 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017505 VANDF LOOM
http://bmi.utah.edu/ontologies/hfontology/C0022209 HFO LOOM
http://www.gamuts.net/entity#isoniazid GAMUTS LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/81335000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/81335000 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.394.582 RH-MESH LOOM
http://localhost/plosthes.2017-1#10068 PLOSTHES LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145890 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000145890 NDFRT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387472004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387472004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/NDDF/002844 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/002844 NDDF LOOM
http://purl.bioontology.org/ontology/LNC/LP15831-8 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP15831-8 LOINC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C600 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C600 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C600 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C600 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C600 NCIT LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005880 DDO LOOM
http://purl.obolibrary.org/obo/DDO.owl#DDO_0005880 DMTO LOOM
http://purl.bioontology.org/ontology/UATC/J04AC01 ATC CUI
http://purl.bioontology.org/ontology/UATC/J04AC01 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D007538 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D007538 MESH CUI
http://purl.bioontology.org/ontology/MESH/D007538 MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/6038 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/6038 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.066.349.410 RH-MESH LOOM
http://scai.fraunhofer.de/MSOntology#Isoniazid MSO LOOM
http://purl.bioontology.org/ontology/MSHFRE/D007538 MSHFRE CUI
http://purl.bioontology.org/ontology/CSP/0316-4065 CRISP CUI
http://purl.bioontology.org/ontology/CSP/0316-4065 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.442.436 RH-MESH LOOM
http://purl.obolibrary.org/obo/dinto_DB00951 DINTO LOOM
http://purl.bioontology.org/ontology/SCTSPA/387472004 SCTSPA CUI