Physician Data Query

Last uploaded: November 18, 2019
Preferred Name

spironolactone

Synonyms

Aldactone

Definitions

A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C840" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C840" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039444

altLabel

Aldactone

Spiroctan

SPL

17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate

SC 9420

CAS Registry

52-01-7

cui

C0037982

C0591054

C0701468

C0592132

Date last modified

2015-10-02

definition

A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature. This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C840" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C840" NCI Thesaurus)

IND Code

11222

Legacy PDQ ID

2079

LT

TRD

NCI ID

C840

notation

CDR0000039444

NSC Code

150399

ORIG STY

Drug/agent

prefLabel

spironolactone

tui

T109

T121

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http://purl.bioontology.org/ontology/MSHFRE/D013148 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D013148 MSHFRE CUI
http://purl.bioontology.org/ontology/RCD/b43.. RCD CUI
http://purl.bioontology.org/ontology/RCD/b43.. RCD LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C840 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C840 NCIT LOOM
http://purl.bioontology.org/ontology/SNMI/C-72420 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-72420 SNMI LOOM
http://purl.bioontology.org/ontology/SCTSPA/13929005 SCTSPA CUI
http://purl.bioontology.org/ontology/SNMI/C-C10CE SNMI CUI
http://purl.bioontology.org/ontology/NDDF/002211 NDDF CUI
http://purl.jp/bio/4/id/200906028579154843 IOBC LOOM
http://purl.bioontology.org/ontology/LNC/LP16280-7 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP16280-7 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/x02rO RCD CUI
http://purl.bioontology.org/ontology/RCD/x02T5 RCD CUI
http://purl.bioontology.org/ontology/CSP/2794-2536 CRISP CUI
http://purl.bioontology.org/ontology/CSP/2794-2536 CRISP LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.745.855 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D013148 MESH CUI
http://purl.bioontology.org/ontology/MESH/D013148 MESH CUI
http://purl.bioontology.org/ontology/MESH/D013148 MESH CUI
http://purl.bioontology.org/ontology/MESH/D013148 MESH LOOM
https://bioportal.bioontology.org/ontologies/FTDM.owl#spironolactone FASTO LOOM
http://www.ifomis.org/acgt/1.0#Spironolactone ACGT-MO LOOM
http://purl.bioontology.org/ontology/UATC/C03DA01 ATC CUI
http://purl.bioontology.org/ontology/UATC/C03DA01 ATC LOOM
http://purl.bioontology.org/ontology/SCTSPA/387078006 SCTSPA CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.540.679 RH-MESH LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003227 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU003227 LOINC LOOM
http://www.drugbank.ca/drugs/DB00421 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4017881 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4017881 VANDF LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146234 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146234 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013148 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_9241 NIFSTD LOOM
http://purl.obolibrary.org/obo/XCO_0000627 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000627 XCO LOOM
http://purl.obolibrary.org/obo/XCO_0000627 XCO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/13929005 SNOMEDCT CUI
http://www.co-ode.org/ontologies/galen#Spironolactone GALEN LOOM
http://purl.bioontology.org/ontology/RXNORM/9997 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/9997 RXNORM LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000005900 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387078006 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/387078006 SNOMEDCT LOOM
http://bmi.utah.edu/ontologies/hfontology/C0037982 HFO LOOM
http://stirdf.jst.go.jp/id/200907023665510166 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D002191 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/151317 RXNORM CUI
http://sbmi.uth.tmc.edu/ontology/ochv#C0037982 OCHV LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#11637 OCHV LOOM