loading...| Preferred Name |
recombinant oxytocin |
|
| Synonyms |
Pitocin |
|
| Definitions |
A synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone oxytocin. Oxytocin binds to oxytocin receptors in the uterine myometrium, which triggers the G-protein coupled receptor signal transduction cascade that causes increased intracellular calcium concentrations. Increased calcium concentration levels activate myosin light chain kinase which, in turn, induces the formation of the contractile protein actomyosin. This stimulates uterine smooth muscle contractions. This agent also stimulates smooth muscles in the mammary glands, thereby causing lactation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C724" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C724" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039293 |
|
| altLabel |
Pitocin oxytocin Syntocinon |
|
| CAS Registry |
50-56-6 |
|
| cui |
C1704206 C0733348 C0030095 C0592155 |
|
| Date last modified |
2015-09-15 |
|
| definition |
A synthetic cyclic peptide form of the naturally occurring posterior pituitary hormone oxytocin. Oxytocin binds to oxytocin receptors in the uterine myometrium, which triggers the G-protein coupled receptor signal transduction cascade that causes increased intracellular calcium concentrations. Increased calcium concentration levels activate myosin light chain kinase which, in turn, induces the formation of the contractile protein actomyosin. This stimulates uterine smooth muscle contractions. This agent also stimulates smooth muscles in the mammary glands, thereby causing lactation. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C724" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C724" NCI Thesaurus) |
|
| Legacy PDQ ID |
1926 |
|
| LT |
TRD |
|
| NCI ID |
C724 |
|
| notation |
CDR0000039293 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
recombinant oxytocin |
|
| tui |
T125 T116 T121 |