Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

norethindrone acetate

Synonyms

nor-Q.D.

Definitions

The orally bioavailable acetate salt of norethindrone, a synthetic progestin with some anabolic, estrogenic, and androgenic activities. As do all progestins, norethindrone binds to and activates nuclear progesterone receptors (PRs) in target tissues such as the pituitary and reproductive system; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes, followed by various transcriptional events and histone acetylation. Physiological effects include the inhibition of luteinizing hormone (LH) release, an increase in the endometrial luteal-phase, and alterations in endocervical mucus secretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C702" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C702" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039254

altLabel

nor-Q.D.

norethisterone acetate

Aygestin

Norlutate

Ortho Micronor

CAS Registry

51-98-9

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000043368

cui

C0068980

C0699160

C0700709

C0699165

C0718752

Date last modified

2017-10-30

definition

The orally bioavailable acetate salt of norethindrone, a synthetic progestin with some anabolic, estrogenic, and androgenic activities. As do all progestins, norethindrone binds to and activates nuclear progesterone receptors (PRs) in target tissues such as the pituitary and reproductive system; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes, followed by various transcriptional events and histone acetylation. Physiological effects include the inhibition of luteinizing hormone (LH) release, an increase in the endometrial luteal-phase, and alterations in endocervical mucus secretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C702" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C702" NCI Thesaurus)

Legacy PDQ ID

1881

LT

TRD

NCI ID

C702

notation

CDR0000039254

NSC Code

9564

ORIG STY

Drug/agent

prefLabel

norethindrone acetate

tui

T125

T109

T121

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http://purl.bioontology.org/ontology/MSHFRE/D000077563 MSHFRE CUI
http://purl.bioontology.org/ontology/MESH/D009640 MESH CUI
http://purl.bioontology.org/ontology/SNMI/C-C2048 SNMI CUI
http://purl.bioontology.org/ontology/MESH/D009640 MESH CUI
http://purl.bioontology.org/ontology/RXNORM/215496 RXNORM CUI
http://purl.bioontology.org/ontology/NDDF/001299 NDDF CUI
http://purl.bioontology.org/ontology/SNOMEDCT/126104005 SNOMEDCT CUI
http://purl.bioontology.org/ontology/VANDF/4018495 VANDF CUI
http://purl.bioontology.org/ontology/SCTSPA/126104005 SCTSPA CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179203 NDFRT CUI
http://purl.bioontology.org/ontology/RXNORM/31983 RXNORM CUI
http://purl.bioontology.org/ontology/SNMI/C-A1231 SNMI CUI
http://purl.bioontology.org/ontology/NDFRT/N0000146817 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/D000077563 MESH CUI
http://purl.bioontology.org/ontology/NDDF/005925 NDDF CUI
http://purl.bioontology.org/ontology/RCD/x02ix RCD CUI
http://purl.bioontology.org/ontology/MESH/D000077563 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000077563 MESH CUI
http://purl.bioontology.org/ontology/NDDF/001299 NDDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/126104005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/VANDF/4018495 VANDF LOOM
http://purl.bioontology.org/ontology/RXNORM/31983 RXNORM LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14516 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C702 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146817 NDFRT LOOM
http://purl.obolibrary.org/obo/NCIT_C702 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0068980 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C024262 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D000077563 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/005925 NDDF LOOM