Preferred Name |
norethindrone acetate |
|
Synonyms |
nor-Q.D. |
|
Definitions |
The orally bioavailable acetate salt of norethindrone, a synthetic progestin with some anabolic, estrogenic, and androgenic activities. As do all progestins, norethindrone binds to and activates nuclear progesterone receptors (PRs) in target tissues such as the pituitary and reproductive system; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes, followed by various transcriptional events and histone acetylation. Physiological effects include the inhibition of luteinizing hormone (LH) release, an increase in the endometrial luteal-phase, and alterations in endocervical mucus secretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C702" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C702" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039254 |
|
altLabel |
nor-Q.D. norethisterone acetate Aygestin Norlutate Ortho Micronor |
|
CAS Registry |
51-98-9 |
|
Component of | ||
cui |
C0068980 C0699160 C0700709 C0699165 C0718752 |
|
Date last modified |
2017-10-30 |
|
definition |
The orally bioavailable acetate salt of norethindrone, a synthetic progestin with some anabolic, estrogenic, and androgenic activities. As do all progestins, norethindrone binds to and activates nuclear progesterone receptors (PRs) in target tissues such as the pituitary and reproductive system; ligand-receptor complexes are translocated to the nucleus where they bind to progesterone response elements (PREs) located on target genes, followed by various transcriptional events and histone acetylation. Physiological effects include the inhibition of luteinizing hormone (LH) release, an increase in the endometrial luteal-phase, and alterations in endocervical mucus secretion. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C702" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C702" NCI Thesaurus) |
|
Legacy PDQ ID |
1881 |
|
LT |
TRD |
|
NCI ID |
C702 |
|
notation |
CDR0000039254 |
|
NSC Code |
9564 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
norethindrone acetate |
|
tui |
T125 T109 T121 |