loading...| Preferred Name |
furosemide |
|
| Synonyms |
Lasix |
|
| Definitions |
An anthranilic derivative and loop diuretic with antihypertensive effect. Furosemide blocks the Na-K-Cl cotransporter (NKCC) in the luminal membrane of the thick ascending limb of the loop of Henle in the kidney, by binding to the Cl-binding site located in the cotransporter's transmembrane domain, thereby inhibiting reabsorption of sodium, chloride, potassium ions and water. This agent reduces plasma and extracellular fluid volume resulting in decreased blood pressure and cardiac output. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C515" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C515" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039247 |
|
| altLabel |
Lasix FRS LB-502 SK-Furosemide |
|
| CAS Registry |
54-31-9 |
|
| cui |
C0699992 C0016860 C1328667 C0700686 |
|
| definition |
An anthranilic derivative and loop diuretic with antihypertensive effect. Furosemide blocks the Na-K-Cl cotransporter (NKCC) in the luminal membrane of the thick ascending limb of the loop of Henle in the kidney, by binding to the Cl-binding site located in the cotransporter's transmembrane domain, thereby inhibiting reabsorption of sodium, chloride, potassium ions and water. This agent reduces plasma and extracellular fluid volume resulting in decreased blood pressure and cardiac output. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C515" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C515" NCI Thesaurus) |
|
| Legacy PDQ ID |
1869 |
|
| LT |
TRD |
|
| NCI ID |
C515 |
|
| notation |
CDR0000039247 |
|
| NSC Code |
269420 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
furosemide |
|
| tui |
T109 T121 |