Preferred Name |
flurbiprofen |
|
Synonyms |
E-7869 |
|
Definitions |
A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C508" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C508" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039245 |
|
altLabel |
E-7869 BTS 18,322 MPC-7869 Ansaid 2-fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid U-27,182 |
|
CAS Registry |
5104-49-4 |
|
cui |
C1527219 C0016377 C0700847 C0700848 C1527220 C0700849 |
|
definition |
A derivative of propionic acid, and a phenylalkanoic acid derivative of non-steroidal antiinflammatory drugs (NSAIDs) with analgesic, antiinflammatory and antipyretic effects. Flurbiprofen non-selectively binds to and inhibits cyclooxygenase (COX). This results in a reduction of arachidonic acid conversion into prostaglandins that are involved in the regulation of pain, inflammation and fever. This NSAID also inhibits carbonic anhydrase, thereby reducing the production of hydrogen and bicarbonate ions. Upon ocular administration, flurbiprofen may reduce bicarbonate ion concentrations leading to a decrease in the production of aqueous humor, thereby lowering intraocular pressure. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C508" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C508" NCI Thesaurus) |
|
Legacy PDQ ID |
1867 |
|
LT |
TRD |
|
NCI ID |
C508 |
|
notation |
CDR0000039245 |
|
NSC Code |
685701 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
flurbiprofen |
|
tui |
T109 T121 |