Physician Data Query

Last uploaded: January 31, 2024
Preferred Name

fludarabine phosphate

Synonyms

Beneflur

Definitions

The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1102" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1102" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039244

altLabel

Beneflur

SH T 586

fludarabine-5'-monophosphate

2-F-ara-AMP

fludarabine monophosphate

9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)

CAS Registry

75607-67-9

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000042430

http://purl.bioontology.org/ontology/PDQ/CDR0000043570

http://purl.bioontology.org/ontology/PDQ/CDR0000039459

http://purl.bioontology.org/ontology/PDQ/CDR0000037865

http://purl.bioontology.org/ontology/PDQ/CDR0000041797

http://purl.bioontology.org/ontology/PDQ/CDR0000361787

http://purl.bioontology.org/ontology/PDQ/CDR0000037972

http://purl.bioontology.org/ontology/PDQ/CDR0000365542

http://purl.bioontology.org/ontology/PDQ/CDR0000257897

http://purl.bioontology.org/ontology/PDQ/CDR0000392734

http://purl.bioontology.org/ontology/PDQ/CDR0000420822

http://purl.bioontology.org/ontology/PDQ/CDR0000037936

http://purl.bioontology.org/ontology/PDQ/CDR0000357440

http://purl.bioontology.org/ontology/PDQ/CDR0000438798

http://purl.bioontology.org/ontology/PDQ/CDR0000041344

http://purl.bioontology.org/ontology/PDQ/CDR0000340992

http://purl.bioontology.org/ontology/PDQ/CDR0000043563

http://purl.bioontology.org/ontology/PDQ/CDR0000269712

http://purl.bioontology.org/ontology/PDQ/CDR0000038212

http://purl.bioontology.org/ontology/PDQ/CDR0000423470

http://purl.bioontology.org/ontology/PDQ/CDR0000040909

http://purl.bioontology.org/ontology/PDQ/CDR0000355733

http://purl.bioontology.org/ontology/PDQ/CDR0000445106

http://purl.bioontology.org/ontology/PDQ/CDR0000269777

http://purl.bioontology.org/ontology/PDQ/CDR0000041309

http://purl.bioontology.org/ontology/PDQ/CDR0000042627

http://purl.bioontology.org/ontology/PDQ/CDR0000043262

http://purl.bioontology.org/ontology/PDQ/CDR0000042240

http://purl.bioontology.org/ontology/PDQ/CDR0000043484

http://purl.bioontology.org/ontology/PDQ/CDR0000367332

http://purl.bioontology.org/ontology/PDQ/CDR0000327799

http://purl.bioontology.org/ontology/PDQ/CDR0000038416

http://purl.bioontology.org/ontology/PDQ/CDR0000041152

http://purl.bioontology.org/ontology/PDQ/CDR0000353319

http://purl.bioontology.org/ontology/PDQ/CDR0000357562

http://purl.bioontology.org/ontology/PDQ/CDR0000407237

http://purl.bioontology.org/ontology/PDQ/CDR0000039027

http://purl.bioontology.org/ontology/PDQ/CDR0000361545

http://purl.bioontology.org/ontology/PDQ/CDR0000039427

http://purl.bioontology.org/ontology/PDQ/CDR0000434637

http://purl.bioontology.org/ontology/PDQ/CDR0000439948

http://purl.bioontology.org/ontology/PDQ/CDR0000322038

http://purl.bioontology.org/ontology/PDQ/CDR0000436065

http://purl.bioontology.org/ontology/PDQ/CDR0000038429

http://purl.bioontology.org/ontology/PDQ/CDR0000038187

http://purl.bioontology.org/ontology/PDQ/CDR0000043093

http://purl.bioontology.org/ontology/PDQ/CDR0000038540

http://purl.bioontology.org/ontology/PDQ/CDR0000041754

http://purl.bioontology.org/ontology/PDQ/CDR0000299063

http://purl.bioontology.org/ontology/PDQ/CDR0000269680

http://purl.bioontology.org/ontology/PDQ/CDR0000357500

http://purl.bioontology.org/ontology/PDQ/CDR0000257920

http://purl.bioontology.org/ontology/PDQ/CDR0000038585

http://purl.bioontology.org/ontology/PDQ/CDR0000428357

http://purl.bioontology.org/ontology/PDQ/CDR0000371731

http://purl.bioontology.org/ontology/PDQ/CDR0000043004

http://purl.bioontology.org/ontology/PDQ/CDR0000409550

http://purl.bioontology.org/ontology/PDQ/CDR0000038500

http://purl.bioontology.org/ontology/PDQ/CDR0000037971

http://purl.bioontology.org/ontology/PDQ/CDR0000037784

http://purl.bioontology.org/ontology/PDQ/CDR0000043216

http://purl.bioontology.org/ontology/PDQ/CDR0000042925

http://purl.bioontology.org/ontology/PDQ/CDR0000038487

http://purl.bioontology.org/ontology/PDQ/CDR0000276583

cui

C0060483

C1831841

C4281921

Date last modified

2016-09-09

definition

The phosphate salt of a fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1102" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1102" NCI Thesaurus)

Legacy PDQ ID

1866

LT

TRD

NCI ID

C1102

notation

CDR0000039244

ORIG STY

Drug/agent

prefLabel

fludarabine phosphate

tui

T114

T121

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Delete Mapping To Ontology Source
http://purl.bioontology.org/ontology/NDFRT/N0000148119 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/C042382 MESH CUI
http://purl.bioontology.org/ontology/VANDF/4020177 VANDF CUI
http://purl.bioontology.org/ontology/RXNORM/25102 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/108765002 SCTSPA CUI
http://purl.bioontology.org/ontology/NDDF/003618 NDDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000179136 NDFRT CUI
http://purl.bioontology.org/ontology/MESH/C042382 MESH CUI
http://purl.bioontology.org/ontology/SNOMEDCT/108765002 SNOMEDCT CUI
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148119 ODAE LOOM
http://www.co-ode.org/ontologies/galen#FludarabinePhosphate GALEN LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148119 NDFRT LOOM
http://purl.bioontology.org/ontology/VANDF/4020177 VANDF LOOM
http://purl.obolibrary.org/obo/CHEBI_31616 BIOMODELS LOOM
http://purl.jp/bio/4/id/200906032149115990 IOBC LOOM
http://purl.obolibrary.org/obo/CHEBI_63599 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_63599 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63599 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_63599 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_63599 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_63599 CHEBI LOOM
http://purl.bioontology.org/ontology/RXNORM/25102 RXNORM LOOM
http://purl.obolibrary.org/obo/NCIT_C1102 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/003618 NDDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1102 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/C042382 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/108765002 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C042382 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907001056783780 IOBC LOOM