loading...| Preferred Name |
fludrocortisone acetate |
|
| Synonyms |
fludrocortisone |
|
| Definitions |
The acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1103" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1103" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039243 |
|
| altLabel |
fludrocortisone Florinef acetate Florinef |
|
| CAS Registry |
514-36-3 |
|
| cui |
C0016280 C0616274 C0060486 |
|
| Date last modified |
2017-10-30 |
|
| definition |
The acetate salt of a synthetic fluorinated corticosteroid with antiinflammatory and antiallergic activities. As a glucocorticoid-receptor agonist, fludrocortisone binds to cytoplasmic receptors, translocates to the nucleus, and subsequently initiates the transcription of glucocorticoid-responsive genes such as lipocortins to inhibit phospholipase A2 (PLA2). Inhibition of PLA2 activity prevents the release of arachidonic acid, a precursor of eicosanoids such as prostaglandins and leukotrienes; eicosanoids are important mediators in the pro-inflammatory response mechanism. As a mineralocorticoid-receptor agonist, this agent stimulates Na+ reabsorption and water retention and K+ and H+ secretion in the distal tubules and collecting ducts of the kidney. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1103" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1103" NCI Thesaurus) |
|
| Legacy PDQ ID |
1865 |
|
| LT |
TRD |
|
| NCI ID |
C1103 |
|
| notation |
CDR0000039243 |
|
| NSC Code |
15186 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
fludrocortisone acetate |
|
| tui |
T125 T109 T121 |