loading...| Preferred Name |
conjugated estrogens |
|
| Synonyms |
EST |
|
| Definitions |
Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C482" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C482" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039237 |
|
| altLabel |
EST Femest Premarin Sodestrin Conestron Tag-39 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000357305 http://purl.bioontology.org/ontology/PDQ/CDR0000039791 http://purl.bioontology.org/ontology/PDQ/CDR0000038466 |
|
| cui |
C0701269 C0701268 C0699710 C0701270 C0701271 C0014938 |
|
| Date last modified |
2006-07-31 |
|
| definition |
Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C482" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C482" NCI Thesaurus) |
|
| Legacy PDQ ID |
1859 |
|
| LT |
TRD |
|
| NCI ID |
C482 |
|
| notation |
CDR0000039237 |
|
| NSC Code |
18313 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
conjugated estrogens |
|
| tui |
T125 T109 T121 |