Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

cefotaxime

Synonyms

Claforan

Definitions

A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39177&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39177&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C354" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039177

altLabel

Claforan

CAS Registry

63527-52-6

cui

C0701052

C0007554

Date last modified

2006-12-12

definition

A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39177&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39177&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C354" NCI Thesaurus)

Legacy PDQ ID

1797

LT

TRD

NCI ID

C354

notation

CDR0000039177

ORIG STY

Drug/agent

prefLabel

cefotaxime

tui

T109

T195

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http://purl.bioontology.org/ontology/NDFRT/N0000005835 NDFRT CUI
http://purl.bioontology.org/ontology/UATC/J01DD01 ATC CUI
http://purl.bioontology.org/ontology/UATC/J01DD01 ATC LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002074 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU002074 LOINC LOOM
http://purl.bioontology.org/ontology/RCD/x02XS RCD CUI
http://purl.bioontology.org/ontology/SNOMEDCT/372704003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/372704003 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/LP14831-9 LOINC CUI
http://purl.bioontology.org/ontology/LNC/LP14831-9 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.665.074.190.190 RH-MESH LOOM
http://purl.bioontology.org/ontology/RCD/e63.. RCD CUI
http://purl.bioontology.org/ontology/SCTSPA/3334000 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/203573 RXNORM CUI
http://purl.bioontology.org/ontology/MSHFRE/D002439 MSHFRE CUI
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.589.099.249.190.190 RH-MESH LOOM
http://purl.bioontology.org/ontology/NDDF/004845 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/004845 NDDF LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C354 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C354 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C354 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C354 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C354 NCIT LOOM
http://purl.jp/bio/4/id/200906042877350186 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D002439 MESH CUI
http://purl.bioontology.org/ontology/MESH/D002439 MESH CUI
http://purl.bioontology.org/ontology/MESH/D002439 MESH LOOM
http://www.co-ode.org/ontologies/galen#Cefotaxime GALEN LOOM
http://purl.bioontology.org/ontology/SNMI/C-53530 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-53530 SNMI LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147755 NDFRT CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147755 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.075.080.875.099.221.249.190.190 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/3334000 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/3334000 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002439 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/2186 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/2186 RXNORM LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 NBO LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_204928 NIFSTD LOOM
http://purl.bioontology.org/ontology/VANDF/4019663 VANDF CUI
http://purl.bioontology.org/ontology/VANDF/4019663 VANDF LOOM
http://id.loc.gov/authorities/subjects/sh90001869 FAST-TOPICAL LOOM
http://purl.bioontology.org/ontology/SCTSPA/372704003 SCTSPA CUI