loading...| Preferred Name |
cefotaxime |
|
| Synonyms |
Claforan |
|
| Definitions |
A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C354" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C354" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039177 |
|
| altLabel |
Claforan |
|
| CAS Registry |
63527-52-6 |
|
| cui |
C0007554 C0701052 |
|
| Date last modified |
2006-12-12 |
|
| definition |
A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C354" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C354" NCI Thesaurus) |
|
| Legacy PDQ ID |
1797 |
|
| LT |
TRD |
|
| NCI ID |
C354 |
|
| notation |
CDR0000039177 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
cefotaxime |
|
| tui |
T109 T195 |