loading...| Preferred Name |
diaziquone |
|
| Synonyms |
CI-904 |
|
| Definitions |
A synthetic bifunctional quinone derivative with potential antineoplastic activity. Diaziquone alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent can also form free radicals, thereby initiating DNA damage via DNA strand breaks. Due to its lipophilicity, diaziquone readily crosses the blood brain barrier. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1363" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1363" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039161 |
|
| altLabel |
CI-904 2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone Aziridinylbenzoquinone carbamic acid Aziridinyl Benzoquinone 2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-dicarbamic acid diethyl ester AZQ carbamic acid, [2,5-bis(1-aziridinyl)-3,6-dioxo-1, 4-cyclohexadiene-1,4-diyl]bis-, diethyl ester (9CI) aziridinylbenzoquinone 1,4-cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl ester [2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]biscarbamic acid diethyl ester 2,5-bis(1-aciridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone 1,4-cyclohexadiene-1,4-dicarbamic acid,2,5-bis(1-aziridinyl)-3,6-dioxo,-diethyl ester 2,5-diaziridinyl-3,6-bis(ethoxycarbonyl-amino)-1,4-benzoquinone |
|
| CAS Registry |
57998-68-2 |
|
| Component of |
http://purl.bioontology.org/ontology/PDQ/CDR0000041343 http://purl.bioontology.org/ontology/PDQ/CDR0000039094 http://purl.bioontology.org/ontology/PDQ/CDR0000039032 |
|
| cui |
C0109747 C0113600 |
|
| definition |
A synthetic bifunctional quinone derivative with potential antineoplastic activity. Diaziquone alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent can also form free radicals, thereby initiating DNA damage via DNA strand breaks. Due to its lipophilicity, diaziquone readily crosses the blood brain barrier. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C1363" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C1363" NCI Thesaurus) |
|
| IND Code |
16707 |
|
| Legacy PDQ ID |
1781 |
|
| NCI ID |
C1363 |
|
| notation |
CDR0000039161 |
|
| NSC Code |
182986 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
diaziquone |
|
| tui |
T109 T121 |