Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

azathioprine sodium

Synonyms

Imuran

Definitions

The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47961" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039157

altLabel

Imuran

Imurel

CAS Registry

55774-33-9

cui

C0699280

C0699279

C0887732

Date last modified

2017-10-23

definition

The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47961" NCI Thesaurus)

Legacy PDQ ID

1777

LT

TRD

NCI ID

C47961

notation

CDR0000039157

NSC Code

39084

ORIG STY

Drug/agent

prefLabel

azathioprine sodium

tui

T109

T131

T121

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http://purl.bioontology.org/ontology/RCD/x02fV RCD CUI
http://www.co-ode.org/ontologies/galen#AzathioprineSodium GALEN LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/67221004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/67221004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/MSHFRE/D001379 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D001379 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D001379 MSHFRE CUI
http://purl.bioontology.org/ontology/SNMI/C-B7041 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-B7041 SNMI LOOM
http://purl.bioontology.org/ontology/NDDF/004123 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/004123 NDDF LOOM
http://purl.bioontology.org/ontology/RXNORM/202559 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/67221004 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/267476 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/267476 RXNORM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/D001379 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001379 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001379 MESH CUI