Preferred Name |
azathioprine sodium |
|
Synonyms |
Imuran |
|
Definitions |
The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47961" NCI Thesaurus) |
|
ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039157 |
|
altLabel |
Imuran Imurel |
|
CAS Registry |
55774-33-9 |
|
cui |
C0887732 C0699279 C0699280 |
|
Date last modified |
2017-10-23 |
|
definition |
The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C47961" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C47961" NCI Thesaurus) |
|
Legacy PDQ ID |
1777 |
|
LT |
TRD |
|
NCI ID |
C47961 |
|
notation |
CDR0000039157 |
|
NSC Code |
39084 |
|
ORIG STY |
Drug/agent |
|
prefLabel |
azathioprine sodium |
|
tui |
T109 T131 T121 |