Physician Data Query

Last uploaded: July 6, 2018
Preferred Name

azathioprine sodium

Synonyms

Imuran

Definitions

The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39157&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39157&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47961" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039157

altLabel

Imuran

AZA

Imurel

AZTP

CAS Registry

446-86-6

cui

C0699280

C0699279

C0887732

C0004482

Date last modified

2006-12-12

definition

The sodium salt form of azathioprine, a pro-drug of purine analogue with immunosuppressive activity. Azathioprine is converted in vivo to its active metabolite 6-mercaptopurine (6-MP), which substitutes for the normal nucleoside and mistakenly gets incorporated into DNA sequences. This leads to inhibition of DNA, RNA, and protein synthesis. As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39157&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39157&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47961" NCI Thesaurus)

Legacy PDQ ID

1777

LT

TRD

NCI ID

C47961

notation

CDR0000039157

NSC Code

39084

ORIG STY

Drug/agent

prefLabel

azathioprine sodium

tui

T109

T131

T121

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http://purl.bioontology.org/ontology/RCD/x02fV RCD CUI
http://www.co-ode.org/ontologies/galen#AzathioprineSodium GALEN LOOM
http://purl.bioontology.org/ontology/CSP/2910-8851 CRISP CUI
http://purl.bioontology.org/ontology/SNOMEDCT/67221004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/67221004 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/1256 RXNORM CUI
http://purl.bioontology.org/ontology/LNC/LP18898-4 LOINC CUI
http://purl.bioontology.org/ontology/LNC/MTHU006794 LOINC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000147069 NDFRT CUI
http://purl.bioontology.org/ontology/SNOMEDCT/372574004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MSHFRE/D001379 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D001379 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D001379 MSHFRE CUI
http://purl.bioontology.org/ontology/MSHFRE/D001379 MSHFRE CUI
http://purl.bioontology.org/ontology/SNMI/C-B7041 SNMI CUI
http://purl.bioontology.org/ontology/SNMI/C-B7041 SNMI LOOM
http://purl.bioontology.org/ontology/NDDF/004123 NDDF CUI
http://purl.bioontology.org/ontology/NDDF/004123 NDDF LOOM
http://purl.bioontology.org/ontology/VANDF/4018766 VANDF CUI
http://purl.bioontology.org/ontology/SCTSPA/111165009 SCTSPA CUI
http://purl.bioontology.org/ontology/RCD/x02MI RCD CUI
http://purl.bioontology.org/ontology/RXNORM/202559 RXNORM CUI
http://purl.bioontology.org/ontology/SCTSPA/372574004 SCTSPA CUI
http://purl.bioontology.org/ontology/SCTSPA/67221004 SCTSPA CUI
http://purl.bioontology.org/ontology/RXNORM/267476 RXNORM CUI
http://purl.bioontology.org/ontology/RXNORM/267476 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/003419 NDDF CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47961 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/111165009 SNOMEDCT CUI
http://purl.bioontology.org/ontology/SNMI/C-B7040 SNMI CUI
http://purl.bioontology.org/ontology/MESH/D001379 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001379 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001379 MESH CUI
http://purl.bioontology.org/ontology/MESH/D001379 MESH CUI
http://purl.bioontology.org/ontology/UATC/L04AX01 ATC CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005799 NDFRT CUI