loading...| Preferred Name |
azaserine |
|
| Synonyms |
diazoacetate (ester) L-Serine |
|
| Definitions |
A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C289" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C289" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000039156 |
|
| altLabel |
diazoacetate (ester) L-Serine AZAS AZS CN-15757 diazoacetylserine O-diazoacetyl-L-serine diazoacetic acid ester with serine L-serine diazoacetate (ester) serine diazoacetate CL-337 P-165 L-diazoacetate (ester) serine |
|
| CAS Registry |
115-02-6 |
|
| cui |
C1527372 C1527371 C0004480 C1527370 |
|
| Date last modified |
2006-12-12 |
|
| definition |
A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C289" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C289" NCI Thesaurus) |
|
| Legacy PDQ ID |
1776 |
|
| NCI ID |
C289 |
|
| notation |
CDR0000039156 |
|
| NSC Code |
742 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
azaserine |
|
| tui |
T195 T116 T121 |