Physician Data Query

Last uploaded: August 27, 2019
Preferred Name

amphotericin B deoxycholate

Synonyms

Fungizone

Definitions

The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, resulting in depolarization of the membrane; alterations in cell membrane permeability and leakage of important intracellular components; and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62201" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62201" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039143

altLabel

Fungizone

CAS Registry

58501-21-6

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041547

http://purl.bioontology.org/ontology/PDQ/CDR0000041026

cui

C0812405

C0051761

Date last modified

2017-10-23

definition

The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, resulting in depolarization of the membrane; alterations in cell membrane permeability and leakage of important intracellular components; and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C62201" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C62201" NCI Thesaurus)

Legacy PDQ ID

1763

LT

TRD

NCI ID

C62201

notation

CDR0000039143

ORIG STY

Drug/agent

prefLabel

amphotericin B deoxycholate

tui

T109

T195

T121

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62201 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62201 NCIT LOOM
http://purl.bioontology.org/ontology/MESH/D000666 MESH CUI
http://purl.bioontology.org/ontology/MESH/C059765 MESH CUI
http://purl.bioontology.org/ontology/RCD/x02dW RCD CUI