Physician Data Query

Last uploaded: April 29, 2019
Preferred Name

amphotericin B deoxycholate

Synonyms

amphotericin-B

Definitions

The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, resulting in depolarization of the membrane; alterations in cell membrane permeability and leakage of important intracellular components; and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39143&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39143&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62201" NCI Thesaurus)

ID

http://purl.bioontology.org/ontology/PDQ/CDR0000039143

altLabel

amphotericin-B

Fungizone

amphotericin B

Component of

http://purl.bioontology.org/ontology/PDQ/CDR0000041547

http://purl.bioontology.org/ontology/PDQ/CDR0000041026

cui

C0812405

C0051761

C0002679

Date last modified

2006-08-07

definition

The deoxycholate salt of amphotericin B, a polyene antifungal antibiotic produced by Streptomyces nodosus, with antifungal activity. Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, resulting in depolarization of the membrane; alterations in cell membrane permeability and leakage of important intracellular components; and cell rupture. This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39143&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39143&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C62201" NCI Thesaurus)

Legacy PDQ ID

1763

LT

TRD

NCI ID

C62201

notation

CDR0000039143

ORIG STY

Drug/agent

prefLabel

amphotericin B deoxycholate

tui

T109

T195

T121

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http://purl.bioontology.org/ontology/UATC/A07AA07 ATC CUI
http://purl.bioontology.org/ontology/UATC/G01AA03 ATC CUI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62201 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62201 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62201 NCIT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62201 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000145996 NDFRT CUI
http://purl.bioontology.org/ontology/SNMI/C-52B20 SNMI CUI
http://purl.bioontology.org/ontology/LNC/MTHU006779 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/77703004 SNOMEDCT CUI
http://purl.bioontology.org/ontology/RXNORM/732 RXNORM CUI
http://purl.bioontology.org/ontology/LNC/LP15581-9 LOINC CUI
http://purl.bioontology.org/ontology/SNOMEDCT/714520003 SNOMEDCT CUI
http://purl.bioontology.org/ontology/MESH/D000666 MESH CUI
http://purl.bioontology.org/ontology/MESH/D000666 MESH CUI
http://purl.bioontology.org/ontology/UATC/A01AB04 ATC CUI
http://purl.bioontology.org/ontology/UATC/J02AA01 ATC CUI
http://purl.bioontology.org/ontology/CSP/0191-9825 CRISP CUI
http://purl.bioontology.org/ontology/NDDF/002887 NDDF CUI
http://purl.bioontology.org/ontology/MESH/C059765 MESH CUI
http://purl.bioontology.org/ontology/VANDF/4017616 VANDF CUI
http://purl.bioontology.org/ontology/NDFRT/N0000005870 NDFRT CUI
http://purl.bioontology.org/ontology/RCD/x02dW RCD CUI